DNA methylation alterations in Alzheimer's disease

Environmental Epigenetics
Amy S YokoyamaValentina Medici

Abstract

The observation that Alzheimer's disease (AD) patients with similar and even identical genetic backgrounds often present with heterogeneous pathologies has prompted the hypothesis that epigenetics may contribute to AD. While the study of epigenetics encompasses a variety of modifications including histone modifications and non-coding RNAs, much of the research on how epigenetics might impact AD pathology has been focused on DNA methylation. To this end, several studies have characterized DNA methylation alterations in various brain regions of individuals with AD, with conflicting results. This review examines the results of studies analyzing both global and gene-specific DNA methylation changes in AD and also assesses the results of studies analyzing DNA hydroxymethylation in patients with AD.

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Citations

Jul 25, 2019·Alzheimer Disease and Associated Disorders·David Salcedo-TacumaHumberto Arboleda
Mar 7, 2020·Scientific Reports·Zixin HuMomiao Xiong
Feb 14, 2020·International Journal of Molecular Sciences·Dolors Puigoriol-IllamolaMercè Pallàs
Jul 28, 2019·Human Molecular Genetics·Matthew J ArmstrongPeng Jin
Sep 10, 2020·JAD Reports·Kenichiro SatoUNKNOWN for Alzheimer’s Disease Neuroimaging Initiative
Apr 29, 2021·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Zhiqiang WeiXin Li

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