DNA methylation and brain structure and function across the life course: A systematic review.

Neuroscience and Biobehavioral Reviews
Emily N W WheaterJames P Boardman

Abstract

MRI has enhanced our capacity to understand variations in brain structure and function conferred by the genome. We identified 60 studies that report associations between DNA methylation (DNAm) and human brain structure/function. Forty-three studies measured candidate loci DNAm; seventeen measured epigenome-wide DNAm. MRI features included region-of-interest and whole-brain structural, diffusion and functional imaging features. The studies report DNAm-MRI associations for: neurodevelopment and neurodevelopmental disorders; major depression and suicidality; alcohol use disorder; schizophrenia and psychosis; ageing, stroke, ataxia and neurodegeneration; post-traumatic stress disorder; and socio-emotional processing. Consistency between MRI features and differential DNAm is modest. Sources of bias: variable inclusion of comparator groups; different surrogate tissues used; variation in DNAm measurement methods; lack of control for genotype and cell-type composition; and variations in image processing. Knowledge of MRI features associated with differential DNAm may improve understanding of the role of DNAm in brain health and disease, but caution is required because conventions for linking DNAm and MRI data are not established, and c...Continue Reading

Citations

Oct 6, 2020·Frontiers in Cell and Developmental Biology·Qiuyue XuBin Yuan
Feb 4, 2021·Molecular Psychiatry·Ian J DearyW David Hill
Apr 20, 2021·Frontiers in Psychiatry·Anna Starnawska, Ditte Demontis
Jun 4, 2021·Frontiers in Psychology·Isabella Lucia Chiara Mariani WigleyRosario Montirosso
Aug 24, 2021·Journal of Neural Transmission·David ChecknitaKent W Nilsson
Nov 6, 2021·Epigenetics : Official Journal of the DNA Methylation Society·Miruna Carmen BarbuHeather Whalley

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Methods Mentioned

BETA
PCR
SMA
Methyl-Seq
genotyping

Software Mentioned

EpiTYPER®
DARTEL
FreeSurfer
BIANCA
PRISMA
TBSS
SPM8
Scopus
CONN
CIVET

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