DNA methylation and gene expression of TXNIP in adult offspring of women with diabetes in pregnancy

PloS One
Azadeh Houshmand-OeregaardAllan A Vaag

Abstract

Fetal exposure to maternal diabetes increases the risk of type 2 diabetes (T2DM), possibly mediated by epigenetic mechanisms. Low blood TXNIP DNA methylation has been associated with elevated glucose levels and risk of T2DM, and increased skeletal muscle TXNIP gene expression was reported in subjects with impaired glucose metabolism or T2DM. Subcutaneous adipose tissue (SAT) and skeletal muscle play a key role in the control of whole body glucose metabolism and insulin action. The extent to which TXNIP DNA methylation levels are decreased and/or gene expression levels increased in SAT or skeletal muscle of a developmentally programmed at-risk population is unknown. The objective of this study was to investigate TXNIP DNA methylation and gene expression in SAT and skeletal muscle, and DNA methylation in blood, from adult offspring of women with gestational diabetes (O-GDM, n = 82) or type 1 diabetes (O-T1DM, n = 67) in pregnancy compared with offspring of women from the background population (O-BP, n = 57). SAT TXNIP DNA methylation was increased (p = 0.032) and gene expression decreased (p = 0.001) in O-GDM, but these differences were attenuated after adjustment for confounders. Neither blood/muscle TXNIP DNA methylation nor mu...Continue Reading

References

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Citations

Mar 14, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Marica FranzagoEster Vitacolonna
Oct 28, 2019·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders· SarinaLan Yu
Jul 13, 2019·Nature Reviews. Disease Primers·H David McIntyrePeter Damm
Mar 28, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Mirian SamblasAlfredo Martínez
Sep 17, 2020·Nutrients·Monika Słupecka-ZiemilskaMonika Puzianowska-Kuznicka
Oct 17, 2020·American Journal of Reproductive Immunology : AJRI·Soumyalekshmi NairCarlos Salomon

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Methods Mentioned

BETA
biopsies
Assay
PCR
reverse
human

Software Mentioned

PyroMark Assay Design
Ensembl Genome Browser
SPSS

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