DNA methylation and socioeconomic status in a Mexican-American birth cohort

Clinical Epigenetics
Eric S CokerBrenda Eskenazi

Abstract

Maternal social environmental stressors during pregnancy are associated with adverse birth and child developmental outcomes, and epigenetics has been proposed as a possible mechanism for such relationships. In a Mexican-American birth cohort of 241 maternal-infant pairs, cord blood samples were measured for repeat element DNA methylation (LINE-1 and Alu). Linear mixed effects regression was used to model associations between indicators of the social environment (low household income and education, neighborhood-level characteristics) and repeat element methylation. Results from a dietary questionnaire were also used to assess the interaction between maternal diet quality and the social environment on markers of repeat element DNA methylation. After adjusting for confounders, living in the most impoverished neighborhoods was associated with higher cord blood LINE-1 methylation (β = 0.78, 95%CI 0.06, 1.50, p = 0.03). No other neighborhood-, household-, or individual-level socioeconomic indicators were significantly associated with repeat element methylation. We observed a statistical trend showing that positive association between neighborhood poverty and LINE-1 methylation was strongest in cord blood of infants whose mothers repo...Continue Reading

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Citations

Mar 13, 2020·Sociology of Health & Illness·Alejandro MartínezIetza Bojorquez
Jan 13, 2019·Journal of Urban Health : Bulletin of the New York Academy of Medicine·Carmen GiurgescuKaren Patricia Williams
Jan 4, 2022·Breast Cancer Research and Treatment·Jazib GoharLauren E McCullough

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Software Mentioned

Pyro Q - CpG
lmerTest
R
R package : missMDA

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