PMID: 11915942Mar 28, 2002Paper

DNA methylation and the regulation of gene transcription

Cellular and Molecular Life Sciences : CMLS
J T AttwoodB Richardson

Abstract

The regulation of gene transcription is not simply dependent on the presence or absence of DNA-binding transcription factors that turn genes on or off, but also involves processes determining the ability of transcription factors to gain access to and bind their target DNA. Methylation of DNA cytosine bases leads to the inaccessibility of DNA regulatory elements to their transcription factors by a number of mechanisms. Our understanding of DNA methylation has advanced rapidly in recent years with the identification of an increasingly large number of novel proteins involved in this process. These include methylcytosine-binding proteins as well as additional members of the DNA methyltransferase family. The creation of mice with targeted deletions in a number of genes involved in DNA methylation has further elucidated the functions of many of these proteins. The characterization of complexes that contain proteins known to be involved in DNA methylation has led to the identification of additional proteins, especially those involved in histone deacetylation, indicating that DNA methylation and histone deacetylation very likely act in a synergistic fashion to regulate gene transcription. Finally, the implication of DNA methylation in ...Continue Reading

Citations

Sep 25, 2008·Biogerontology·Kyojiro KawakamiRyoya Takahashi
Sep 28, 2012·International Journal of Hematology·Young Rock ChungOmar Abdel-Wahab
Dec 27, 2011·Cancer Letters·Carmen Jerónimo, Rui Henrique
Mar 12, 2004·The Journal of Surgical Research·David S Schrump
Jan 30, 2013·Molecular Aspects of Medicine·W Lee Kraus, Michael O Hottiger
Dec 4, 2003·Pharmacology & Therapeutics·Asterios S TsiftsoglouIoannis S Vizirianakis
Oct 16, 2012·Psychiatry Research·Hui-Chun TsuangHsien-Yuan Lane
Dec 14, 2002·Trends in Biotechnology·Thomas Werner
Dec 4, 2003·Neurochemistry International·Mohammad Tabish, Maharaj K Ticku
Jan 27, 2004·Schizophrenia Research·Hamid Mostafavi AbdolmalekyMing T Tsuang
Oct 31, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Bruce Richardson
Nov 27, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jan Havlis, Martin Trbusek
Dec 6, 2011·Nature Genetics·Grant A ChallenMargaret A Goodell
Jun 10, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dirk MoserJobst Meyer
Apr 1, 2011·Chemical Communications : Chem Comm·Armin ThalhammerChristopher J Schofield
Nov 23, 2006·Bioinformatics·Andreas W Schreiber, Ute Baumann
Nov 7, 2003·Nucleic Acids Research·Christopher D CarvinMichael P Kladde
Mar 28, 2008·Nucleic Acids Research·Karin HoelzerColin R Parrish
Jul 28, 2005·Journal of Biomedicine & Biotechnology·Jonathan D Wren, Harold R Garner
Dec 24, 2010·BMC Medicine·Xiaoling WangHuidong Shi
May 19, 2007·Arthritis Research & Therapy·Andrea L SestakJohn B Harley
Nov 15, 2003·Biological Procedures Online·Raymond L. YungJun Chen
Feb 6, 2013·PloS One·Magdalena Janina LaskaBjørn Andersen Nexø
Jun 14, 2012·Epigenomics·Ran He, Julia A Eggert

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.