DNA methylation as a transcriptional regulator of the immune system

Translational Research : the Journal of Laboratory and Clinical Medicine
Luisa Morales-NebredaBenjamin D Singer

Abstract

DNA methylation is a dynamic epigenetic modification with a prominent role in determining mammalian cell development, lineage identity, and transcriptional regulation. Primarily linked to gene silencing, novel technologies have expanded the ability to measure DNA methylation on a genome-wide scale and uncover context-dependent regulatory roles. The immune system is a prototypic model for studying how DNA methylation patterning modulates cell type- and stimulus-specific transcriptional programs. Preservation of host defense and organ homeostasis depends on fine-tuned epigenetic mechanisms controlling myeloid and lymphoid cell differentiation and function, which shape innate and adaptive immune responses. Dysregulation of these processes can lead to human immune system pathology as seen in blood malignancies, infections, and autoimmune diseases. Identification of distinct epigenotypes linked to pathogenesis carries the potential to validate therapeutic targets in disease prevention and management.

Citations

Jul 3, 2019·American Journal of Respiratory Cell and Molecular Biology·Benjamin D Singer
Mar 4, 2020·The Journal of Clinical Investigation·Luisa Morales-NebredaBenjamin D Singer
Jul 2, 2020·American Journal of Respiratory Cell and Molecular Biology·Andrew D PriggeKaren M Ridge
Sep 29, 2020·Frontiers in Immunology·Maria J GutierrezXiaobin Wang
Nov 17, 2019·Genes·Andrée-Anne Hudon Thibeault, Catherine Laprise
Aug 5, 2020·The European Respiratory Journal·Manuel A Torres Acosta, Benjamin D Singer
May 14, 2019·The Journal of Clinical Investigation·Benjamin D Singer, Navdeep S Chandel
Jul 23, 2019·The Journal of Clinical Investigation·Katarzyna PlacekAnna C Aschenbrenner
Dec 5, 2019·Frontiers in Genetics·José Santiago Ibáñez-CabellosJosé Luis García-Giménez
May 6, 2020·Scientific Reports·Sharon A McGrath-MorrowBenjamin D Singer
Sep 9, 2020·The Journal of Clinical Investigation·Kathryn A HelminBenjamin D Singer
Nov 5, 2019·Journal of Psychiatric Research·Mara ThomasVanessa Nieratschker
Feb 5, 2021·Cancers·Ali Mehdi, Shafaat A Rabbani
Feb 23, 2021·The Journal of Experimental Medicine·Zheng-Jun GaoYi-Yuan Li
Oct 15, 2020·International Journal of Molecular Sciences·Dejan NikolicIvana Novakovic
Mar 13, 2021·Frontiers in Genetics·Mengqi Wang, Eveline M Ibeagha-Awemu
Apr 4, 2021·Nutrients·Jian TanLaurence Macia
Jun 18, 2021·Frontiers in Molecular Biosciences·Yu YangChi Liu
Jun 29, 2021·Seminars in Cancer Biology·Diego M Avella PatinoJonathan B Mitchem
Jul 24, 2021·The Journal of Experimental Medicine·Andrew W Daman, Steven Z Josefowicz
Aug 14, 2021·PLoS Pathogens·Michael J CorleyUNKNOWN SEARCH010/RV254 and SEARCH013/RV304 study groups
Aug 17, 2021·Frontiers in Immunology·Wanhai QinTom van der Poll
Aug 24, 2021·Frontiers in Immunology·Jingli LuChengliang Zhang

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