DNA Methylation-Based Testing in Liquid Biopsies as Detection and Prognostic Biomarkers for the Four Major Cancer Types.

Cells
Vera ConstâncioCarmen Jerónimo

Abstract

Lung, breast, colorectal, and prostate cancers are the most incident worldwide. Optimal population-based cancer screening methods remain an unmet need, since cancer detection at early stages increases the prospects of successful and curative treatment, leading to a lower incidence of recurrences. Moreover, the current parameters for cancer patients' stratification have been associated with divergent outcomes. Therefore, new biomarkers that could aid in cancer detection and prognosis, preferably detected by minimally invasive methods are of major importance. Aberrant DNA methylation is an early event in cancer development and may be detected in circulating cell-free DNA (ccfDNA), constituting a valuable cancer biomarker. Furthermore, DNA methylation is a stable alteration that can be easily and rapidly quantified by methylation-specific PCR methods. Thus, the main goal of this review is to provide an overview of the most important studies that report methylation biomarkers for the detection and prognosis of the four major cancers after a critical analysis of the available literature. DNA methylation-based biomarkers show promise for cancer detection and management, with some studies describing a "PanCancer" detection approach fo...Continue Reading

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Citations

May 14, 2020·Cells·Flavia Lima Costa FaldoniSilvia Regina Rogatto
Sep 15, 2020·Melanoma Management·Russell J DiefenbachHelen Rizos
Dec 19, 2020·Biomolecules·Francesca GalardiMatteo Benelli
Aug 14, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Amedeo GagliardiGiovanni Fiorito
Jan 27, 2021·Proceedings of the National Academy of Sciences of the United States of America·Shengnan JinChunming Ding
Nov 22, 2020·International Journal of Molecular Sciences·Johannes J SchabortJe-Yoel Cho
May 15, 2021·International Journal of General Medicine·Yanhui TangYu Ling
Jun 6, 2021·Journal of Human Genetics·Kazunori WatanabeSiew-Kee Low
Jun 18, 2021·NPJ Precision Oncology·Katrina CristallChristopher R Mueller
Jul 3, 2021·Cancers·Cora Palanca-BallesterAlfonso Calvo

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Methods Mentioned

BETA
biopsy
biopsies
X-ray
PCR
surgical resection

Software Mentioned

MSP
CancerLocator
CancerDetector

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