DNA methylation changes in cervical cancers

Methods in Molecular Biology
Qiang LuShuping Zhao

Abstract

Cervical carcinoma is one of the major causes of death in women worldwide. It is difficult to foresee a dramatic increase in cure rate even with the most optimal combination of cytotoxic drugs, surgery, and radiation; therefore, testing of molecular targeted therapies against this malignancy is highly desirable. Cervical cancer is a multistep process with accumulation of genetic and epigenetic alterations in regulatory genes, leading to activation of oncogenes and inactivation or loss of tumor suppressor genes (TSGs). In the last decade, in addition to genetic alterations, epigenetic inactivation of TSGs by promoter hypermethylation has been recognized as an important and alternative mechanism in tumorigenesis. In cervical cancer, epigenetic alterations can affect the expression of papillomavirus as well as host genes in relation to stages representing the multistep process of carcinogenesis. Here we discuss these epigenetic alterations in cervical cancer focusing on DNA methylation.

Citations

Apr 17, 2014·Oncology Reports·Hilda Jiménez-WencesGloria Fernández-Tilapa
Oct 16, 2013·Cancer Investigation·Marie-Luise BuchholtzAnsgar Brüning
Sep 4, 2012·Clinical Epigenetics·Kathleen P SaavedraJuan Carlos S Roa
Jun 25, 2016·International Journal of Clinical Oncology·Daisuke Sano, Nobuhiko Oridate
Sep 21, 2013·Clinical Chemistry·Denise Uyar, Janet Rader
Oct 9, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Suthipong ChujanApiwat Mutirangura
Jun 24, 2020·Pathogens·Michelle Mac, Cary A Moody
Jul 8, 2019·Gene·Satarupa Banerjee, Devarajan Karunagaran
Jan 15, 2021·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Aissam El AlianiMohammed El Mzibri

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