DNA Methylation Dynamics and Cocaine in the Brain: Progress and Prospects

Genes
Kathryn VaillancourtGustavo Turecki

Abstract

Cytosine modifications, including DNA methylation, are stable epigenetic marks that may translate environmental change into transcriptional regulation. Research has begun to investigate DNA methylation dynamics in relation to cocaine use disorders. Specifically, DNA methylation machinery, including methyltransferases and binding proteins, are dysregulated in brain reward pathways after chronic cocaine exposure. In addition, numerous methylome-wide and candidate promoter studies have identified differential methylation, at the nucleotide level, in rodent models of cocaine abuse and drug seeking behavior. This review highlights the current progress in the field of cocaine-related methylation, and offers considerations for future research.

References

Jul 21, 1998·Annals of the New York Academy of Sciences·B T Hope
Feb 17, 1999·Journal of Biochemistry·T K Kundu, M R Rao
Apr 2, 1999·The European Journal of Neuroscience·N HiroiE J Nestler
Nov 24, 1999·Molecular and Cellular Biology·C L Hsieh
Dec 10, 1999·Cell·A P Bird, A P Wolffe
Oct 18, 2002·European Journal of Biochemistry·Mehrnaz FatemiAlbert Jeltsch
Aug 27, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Venetia ZachariouEric J Nestler
May 4, 2006·Molecular Pharmacology·Suzanne CasselJean Zwiller
Mar 22, 2008·Neurochemical Research·Lars V KristiansenJames H Meador-Woodruff
Nov 5, 2008·The American Journal of Psychiatry·Christopher W CowanCarly F Hale
Dec 5, 2008·PLoS Biology·Vijay K TiwariStephen B Baylin
Mar 25, 2009·Nature Reviews. Genetics·Howard Cedar, Yehudit Bergman
Aug 28, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·George F Koob, Nora D Volkow
Mar 10, 2010·Neurobiology of Disease·Delphine CarougePatrick Anglard
Jul 9, 2010·Nature·Alika K MaunakeaJoseph F Costello
Aug 20, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kaili AnierAnti Kalda
Aug 24, 2010·Nature Neuroscience·Quincey LaPlantEric J Nestler
Apr 6, 2011·Proceedings of the National Academy of Sciences of the United States of America·Zhifeng ZhouDavid Goldman
Aug 30, 2011·Nature Neuroscience·Junjie U GuoHongjun Song
Oct 4, 2011·Nature·Sanjeev ShuklaShalini Oberdoerffer
May 18, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dani DumitriuEric J Nestler
Jul 14, 2012·Journal of Perinatology : Official Journal of the California Perinatal Association·B L Lambert, C R Bauer
Dec 18, 2012·Nature Neuroscience·Fair M VassolerR Christopher Pierce
Feb 8, 2013·Nature Medicine·Bruce T HopeSchahram Akbarian

❮ Previous
Next ❯

Citations

Feb 18, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·R Christopher PierceMathieu E Wimmer
Sep 15, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Morgan E ZipperlyJeremy J Day
Mar 27, 2020·Frontiers in Bioengineering and Biotechnology·Xiaoqian GaoFengfeng Zhou
May 23, 2019·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Caroline CamiloHelena Brentani
Oct 14, 2020·Molecular Psychiatry·Kathryn VaillancourtGustavo Turecki
Apr 24, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Iraia Muñoa-HoyosNerea Subiran
Aug 29, 2021·Molecular Psychiatry·Noèlia Fernàndez-CastilloBru Cormand

❮ Previous
Next ❯

Methods Mentioned

BETA
affinity purification
acetylation
immunoprecipitation
pulldown
FACS
histone acetylation

Software Mentioned

MeDip

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Dialogues in Clinical Neuroscience
Michael J Morris, Lisa M Monteggia
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Lisa D MooreGuoping Fan
Neuroscience Letters
Rami Al-HaddadSama F Sleiman
© 2022 Meta ULC. All rights reserved