DNA methylation dynamics in muscle development and disease

Frontiers in Aging Neuroscience
Elvira Carrió, Mònica Suelves

Abstract

DNA methylation is an essential epigenetic modification for mammalian development and is crucial for the establishment and maintenance of cellular identity. Traditionally, DNA methylation has been considered as a permanent repressive epigenetic mark. However, the application of genome-wide approaches has allowed the analysis of DNA methylation in different genomic contexts revealing a more dynamic regulation than originally thought, since active DNA methylation and demethylation occur during cellular differentiation and tissue specification. Satellite cells are the primary stem cells in adult skeletal muscle and are responsible for postnatal muscle growth, hypertrophy, and muscle regeneration. This review outlines the published data regarding DNA methylation changes along the skeletal muscle program, in both physiological and pathological conditions, to better understand the epigenetic mechanisms that control myogenesis.

Citations

Feb 4, 2016·Stem Cells International·Silvia ConsalviValentina Saccone
Apr 15, 2016·BMC Biology·Elvira CarrióMònica Suelves
Sep 15, 2016·Frontiers in Cell and Developmental Biology·Jessica SegalésPura Muñoz-Cánoves
Jul 15, 2016·Briefings in Functional Genomics·Mònica SuelvesMiguel A Peinado
May 5, 2017·Journal of Cellular Physiology·Seong Y HwangNam D Kim
Sep 8, 2016·Clinical Epigenetics·Fleur A D LeenenJonathan D Turner
Apr 26, 2018·American Journal of Physiology. Cell Physiology·Andrea A DomenighettiRichard L Lieber
Sep 12, 2019·Journal of Cachexia, Sarcopenia and Muscle·Lingxiao HeMartine Thomis
Jun 6, 2019·Epigenetics & Chromatin·Ting ZhangGang Li
Jan 2, 2019·Archives of Pharmacal Research·Seong Yeon HwangNam Deuk Kim
Dec 24, 2019·Journal of Molecular Biology·Haser H SutcuAlexander A Ishchenko
Jun 18, 2021·BMC Genomic Data·Kai WangGuoqing Tang
Jul 17, 2021·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Yaxiong PanJianshe Zhang
Jul 10, 2021·Genome Génome / Conseil National De Recherches Canada·Kai WangGuoqing Tang

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Methods Mentioned

BETA
deamination
Immunoprecipitation
RRBS
immuprecipitation
biopsies
methylation assay
MeDIP-PCR

Software Mentioned

MeDIP
ChIP

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