DNA methylation in a Scottish family multiply affected by bipolar disorder and major depressive disorder.

Clinical Epigenetics
Rosie M WalkerKathryn L Evans

Abstract

Bipolar disorder (BD) is a severe, familial psychiatric condition. Progress in understanding the aetiology of BD has been hampered by substantial phenotypic and genetic heterogeneity. We sought to mitigate these confounders by studying a multi-generational family multiply affected by BD and major depressive disorder (MDD), who carry an illness-linked haplotype on chromosome 4p. Within a family, aetiological heterogeneity is likely to be reduced, thus conferring greater power to detect illness-related changes. As accumulating evidence suggests that altered DNA methylation confers risk for BD and MDD, we compared genome-wide methylation between (i) affected carriers of the linked haplotype (ALH) and married-in controls (MIs), (ii) well unaffected haplotype carriers (ULH) and MI, (iii) ALH and ULH and (iv) all haplotype carriers (LH) and MI. Nominally significant differences in DNA methylation were observed in all comparisons, with differences withstanding correction for multiple testing when the ALH or LH group was compared to the MIs. In both comparisons, we observed increased methylation at a locus in FANCI, which was accompanied by increased FANCI expression in the ALH group. FANCI is part of the Fanconi anaemia complementatio...Continue Reading

References

Apr 1, 1996·Nature Genetics·D H BlackwoodW J Muir
May 14, 2003·Archives of General Psychiatry·Peter McGuffinAlastair Cardno
May 14, 2005·Nature Reviews. Neuroscience·E Ron de KloetFlorian Holsboer
Feb 14, 2006·Molecular Aspects of Medicine·Simone Fleige, Michael W Pfaffl
Oct 3, 2007·PLoS Genetics·Jeffrey T Leek, John D Storey
Mar 6, 2008·American Journal of Human Genetics·Jonathan MillArturas Petronis
Jun 25, 2008·Nature Reviews. Genetics·Greg Gibson
Aug 1, 2008·Nature·UNKNOWN International Schizophrenia Consortium
Aug 1, 2008·Nature·Hreinn StefanssonKari Stefansson
Aug 20, 2008·Nature Genetics·Manuel A R FerreiraUNKNOWN Wellcome Trust Case Control Consortium
Sep 26, 2008·Nature·Yingxi LinMichael E Greenberg
Oct 22, 2008·Nature Structural & Molecular Biology·Masamichi IshiaiMinoru Takata
Dec 24, 2010·Bipolar Disorders·Robert D BeechZubin Bhagwagar
Sep 20, 2011·Nature Genetics·UNKNOWN Psychiatric GWAS Consortium Bipolar Disorder Working Group
Nov 1, 2011·Nature Genetics·Yongyong ShiLin He
Mar 20, 2012·Cell·Dheeraj Malhotra, Jonathan Sebat
May 10, 2012·BMC Bioinformatics·Eugene Andres HousemanKarl T Kelsey
Sep 8, 2012·Science·Matthew T MauranoJohn A Stamatoyannopoulos
Nov 30, 2012·Nucleic Acids Research·Kate R RosenbloomW James Kent
Jan 15, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Yi-an ChenRosanna Weksberg
Jan 17, 2013·Bipolar Disorders·Emma DrysdaleDouglas H R Blackwood
Mar 5, 2013·Lancet·UNKNOWN Cross-Disorder Group of the Psychiatric Genomics Consortium
May 2, 2013·BMC Genomics·Ruth PidsleyLeonard C Schalkwyk
Aug 13, 2013·The International Journal of Neuropsychopharmacology·Tatsuro AsaiKazuya Iwamoto
Aug 16, 2013·BMC Psychiatry·Fayaz SeifuddinPeter P Zandi
Aug 27, 2013·Nature Genetics·Stephan RipkePatrick F Sullivan
Dec 18, 2013·Proceedings of the National Academy of Sciences of the United States of America·Iuliana Ionita-LazaMaria Karayiorgou
Feb 6, 2014·Genome Biology·Andrew E Jaffe, Rafael A Irizarry
Mar 1, 2014·Cell and Tissue Research·Michael J Berridge
Mar 13, 2014·Nature Communications·Thomas W MühleisenSven Cichon

❮ Previous
Next ❯

Citations

Jun 23, 2016·Neuroscience and Biobehavioral Reviews·Gabriel R FriesJoao Quevedo
May 12, 2018·European Journal of Clinical Pharmacology·Peipei WangWeimin Cai
Feb 6, 2019·Translational Psychiatry·Muzi LiXiangfei Meng
Jan 7, 2018·Journal of Human Genetics·Mihoko ShimadaTsukasa Sasaki
Dec 9, 2020·Psychiatric Genetics·Adrien LegrandBoris Chaumette
Jan 29, 2021·Scientific Reports·Hirotaka YamagataShin Nakagawa
Jun 26, 2021·Journal of Psychiatric Research·Zeinab Shirvani-FarsaniIman Sadeghi

❮ Previous
Next ❯

Methods Mentioned

BETA
methylation profiling
exome sequencing
immunoprecipitation
chips
Assay

Software Mentioned

R
minfi
geNorm
R package wateRmelon
R package SVA
R package limma
R package ChAMP
GOrilla

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.