DNA methylation in an intron of the IBM1 histone demethylase gene stabilizes chromatin modification patterns.

The EMBO Journal
Mélanie RigalOlivier Mathieu

Abstract

The stability of epigenetic patterns is critical for genome integrity and gene expression. This highly coordinated process involves interrelated positive and negative regulators that impact distinct epigenetic marks, including DNA methylation and dimethylation at histone H3 lysine 9 (H3K9me2). In Arabidopsis, mutations in the DNA methyltransferase MET1, which maintains CG methylation, result in aberrant patterns of other epigenetic marks, including ectopic non-CG methylation and the relocation of H3K9me2 from heterochromatin into gene-rich chromosome regions. Here, we show that the expression of the H3K9 demethylase IBM1 (increase in BONSAI methylation 1) requires DNA methylation. Surprisingly, the regulatory methylated region is contained in an unusually large intron that is conserved in IBM1 orthologues. The re-establishment of IBM1 expression in met1 mutants restored the wild-type H3K9me2 nuclear patterns, non-CG DNA methylation and transcriptional patterns at selected loci, which included DNA demethylase genes. These results provide a mechanistic explanation for long-standing puzzling observations in met1 mutants and reveal yet another layer of control in the interplay between DNA methylation and histone modification, which...Continue Reading

References

Jun 25, 1993·Science·A VongsE J Richards
Jan 1, 1997·Annual Review of Biochemistry·S M UptainM J Chamberlin
Dec 10, 1999·Cell·A P Bird, A P Wolffe
Dec 29, 2000·Nature·UNKNOWN Arabidopsis Genome Initiative
Jan 10, 2002·Genes & Development·Adrian Bird
Mar 19, 2002·Nature·James P JacksonSteven E Jacobsen
Jul 18, 2002·Current Biology : CB·Xiaofeng Cao, Steven E Jacobsen
Jul 23, 2002·Nature Genetics·Cristian I Castillo-DavisFyodor A Kondrashov
Jul 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Muhammad TariqJerzy Paszkowski
Nov 5, 2003·FEBS Letters·Motoko Unoki, Yusuke Nakamura
Dec 19, 2003·Current Biology : CB·Xiaofeng CaoSteven E Jacobsen
Jan 26, 2005·Current Biology : CB·Robert K TranSteven Henikoff
Feb 24, 2005·Annual Review of Plant Biology·Judith Bender
Mar 8, 2005·Trends in Plant Science·Mansour KarimiPierre Hilson
Apr 30, 2005·Nature Reviews. Genetics·Simon W-L ChanSteven E Jacobsen
Apr 21, 2006·The Plant Journal : for Cell and Molecular Biology·Mingsheng PengSteven J Rothstein
Apr 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Bing-Bing Wang, Volker Brendel
May 2, 2006·Molecular and Cellular Biology·Natalia GromakNick J Proudfoot
May 26, 2006·The EMBO Journal·Bruno HuettelMarjori Matzke
Sep 21, 2006·Nature Reviews. Genetics·Robert J KloseYi Zhang
Dec 19, 2006·Nature Reviews. Genetics·Shiv I S Grewal, Songtao Jia
Jan 24, 2007·Current Biology : CB·Lianna M JohnsonSteven E Jacobsen
Jan 24, 2007·Genes & Development·Hye Ryun WooEric J Richards
Oct 24, 2007·Plant Physiology·Jon PentermanRobert L Fischer

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Citations

Sep 5, 2013·Proceedings of the National Academy of Sciences of the United States of America·Xingang WangJian-Kang Zhu
Jan 10, 2014·PloS One·Vincent CousthamNicolas Bouché
Jan 5, 2014·PloS One·Michal Lieberman-LazarovichAvraham A Levy
Nov 20, 2013·Proceedings of the National Academy of Sciences of the United States of America·Mingguang LeiJian-Kang Zhu
Jul 9, 2014·Proceedings of the National Academy of Sciences of the United States of America·Lanjuan HuBao Liu
Jul 15, 2015·Current Opinion in Plant Biology·Dalen FultzR Keith Slotkin
Aug 22, 2015·Nature Reviews. Molecular Cell Biology·Jiamu DuDinshaw J Patel
Mar 24, 2016·Proceedings of the National Academy of Sciences of the United States of America·Mélanie RigalOlivier Mathieu
Mar 19, 2014·Current Opinion in Plant Biology·Olivier Mathieu, Nicolas Bouché
Jun 17, 2015·Plant & Cell Physiology·Shulin Deng, Nam-Hai Chua
Aug 20, 2014·Stem Cells and Development·Yoshikazu MikamiKazuo Komiyama
May 7, 2016·Genome Biology·William T Jordan, Robert J Schmitz
Aug 6, 2016·Annual Review of Phytopathology·A DelerisL Navarro
Aug 13, 2013·Nature Communications·Hidetoshi SazeTetsuji Kakutani
Aug 16, 2017·Proceedings of the National Academy of Sciences of the United States of America·Cheng-Guo DuanJian-Kang Zhu
Mar 3, 2018·Nature Communications·Lexiang JiRobert J Schmitz
Oct 28, 2017·The Plant Journal : for Cell and Molecular Biology·Dolores Córdoba-CañeroJean Molinier
Apr 8, 2020·Molecular Biology and Evolution·Régis L CorrêaSantiago F Elena
Oct 13, 2016·Annual Review of Genetics·Leandro Quadrana, Vincent Colot
Oct 3, 2018·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Jing LiuWei Hua
Feb 20, 2020·Proceedings of the National Academy of Sciences of the United States of America·Yinwen ZhangRobert J Schmitz
Jan 6, 2017·Nucleic Acids Research·Nicolae Radu ZabetJerzy Paszkowski
Sep 26, 2020·Frontiers in Genetics·Jian ZhangCheng-Guo Duan
Jun 28, 2020·Nature Communications·Ngoc Tu LeHidetoshi Saze
Dec 31, 2020·International Journal of Molecular Sciences·Ahmed MalkiAla-Eddin Al Moustafa
Dec 31, 2020·Proceedings of the National Academy of Sciences of the United States of America·Katherine DombAssaf Zemach
Jul 6, 2015·Plant Physiology·Taiko K ToTetsuji Kakutani
Aug 29, 2021·Proceedings of the National Academy of Sciences of the United States of America·Li HeJian-Kang Zhu

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