DNA methylation in cell differentiation and reprogramming: an emerging systematic view

Regenerative Medicine
Kevin Huang, Guoping Fan

Abstract

Embryonic stem cells have the unique ability to indefinitely self-renew and differentiate into any cell type found in the adult body. Differentiated cells can, in turn, be reprogrammed to embryonic stem-like induced pluripotent stem cells, providing exciting opportunities for achieving patient-specific stem cell therapy while circumventing immunological obstacles and ethical controversies. Since both differentiation and reprogramming are governed by major changes in the epigenome, current directions in the field aim to uncover the epigenetic signals that give pluripotent cells their unique properties. DNA methylation is one of the major epigenetic factors that regulates gene expression in mammals and is essential for establishing cellular identity. Recent analyses of pluripotent and somatic cell methylomes have provided important insights into the extensive role of DNA methylation during cell-fate commitment and reprogramming. In this article, the recent progress of differentiation and reprogramming research illuminated by high-throughput studies is discussed in the context of DNA methylation.

References

Jul 20, 1987·Journal of Molecular Biology·M Gardiner-Garden, M Frommer
Sep 29, 1994·Nature·M BrandeisH Cedar
Jul 25, 1998·Genes & Development·N RougierE Viegas-Péquignot
Nov 6, 1998·Science·J A ThomsonJ M Jones
Apr 2, 1999·Science·M F PittengerD R Marshak
Oct 6, 1999·The Journal of Cell Biology·M C Cardoso, H Leonhardt
Feb 17, 2000·Nature·W MayerT Haaf
May 10, 2000·Current Biology : CB·J OswaldJ Walter
May 11, 2000·Proceedings of the National Academy of Sciences of the United States of America·B H RamsahoyeR Jaenisch
Oct 14, 2000·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·W MayerT Haaf
Jul 4, 2001·Nature Reviews. Neuroscience·S Temple
Aug 11, 2001·Science· Wu Ct, J R Morris
Jan 11, 2002·Developmental Biology·Fátima SantosWendy Dean
Mar 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gregory P WhitePatrick G Holt
Mar 9, 2002·Molecular and Cellular Biology·Detlev BiniszkiewiczRudolf Jaenisch
Mar 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Daiya Takai, Peter A Jones
Jul 12, 2002·The Journal of Biological Chemistry·Sharon Gidekel, Yehudit Bergman
Jul 19, 2003·Journal of Biochemistry·Isao SuetakeShoji Tajima
Apr 3, 2004·Genome Génome / Conseil National De Recherches Canada·Ke-Jing WangYoshihito Takahata
Aug 18, 2004·Genome Research·Naka HattoriKunio Shiota
Jan 25, 2005·Experimental & Molecular Medicine·Seung Cheol ChoiDo-Sun Lim
May 3, 2005·Nature Genetics·Peter J Rugg-GunnRoger A Pedersen
Sep 6, 2005·Nature Genetics·Anirban MaitraAravinda Chakravarti
Jan 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Serge SaxonovDouglas L Brutlag
Feb 8, 2006·Genome Génome / Conseil National De Recherches Canada·A PissardP Bertin
Jul 11, 2006·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Akiko TsumuraMasaki Okano
Aug 11, 2006·Genome Research·Marina BibikovaJian-Bing Fan

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Citations

Feb 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Khursheed IqbalPiroska E Szabó
Apr 4, 2013·BMC Genomics·Neha PandeySamir V Sawant
Oct 22, 2011·Molecular Endocrinology·Joëlle RüeggIngemar Pongratz
Oct 12, 2013·Cellular and Molecular Life Sciences : CMLS·Swayamsiddha KarSamir Kumar Patra
Feb 19, 2013·Journal of Autoimmunity·Yangyang LuoQianjin Lu
Jan 13, 2012·The Journal of Investigative Dermatology·Jeffrey B Cheng, Raymond J Cho
Feb 14, 2014·Journal of Neurochemistry·Inna I Kruman, Anna-Kate Fowler
Oct 2, 2015·International Journal of Epidemiology·Caroline L ReltonGeorge Davey Smith
Feb 6, 2015·Pediatric Diabetes·Nick Giannoukakis, Massimo Trucco
Mar 10, 2015·Stem Cells and Development·Anjana Nityanandam, Kristin K Baldwin
Aug 6, 2014·Epigenetics : Official Journal of the DNA Methylation Society·Hitomi TakadaYasuyuki S Kida
Jul 8, 2016·Neuromolecular Medicine·Saeed AslaniMahmoud Jafarnejad
Apr 19, 2018·Rejuvenation Research·Andrew R Mendelsohn, James W Larrick
Jul 17, 2010·Regenerative Medicine·M William Lensch, Mahendra Rao
Jan 18, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Lea Harrington, Fabio Pucci
Jul 23, 2019·Critical Reviews in Clinical Laboratory Sciences·Peter D Fransquet, Joanne Ryan
Feb 21, 2019·Investigative Ophthalmology & Visual Science·Guangying LuoDongsheng Yan
Sep 9, 2019·Lasers in Medical Science·Arezoo Rezaie Nezhad ZamaniReza Rahbarghazi
May 27, 2014·International Journal of Systematic and Evolutionary Microbiology·Masayuki MiyazakiHiroyuki Imachi
Jun 13, 2017·The Journal of Reproduction and Development·Fujia WuLei An
Feb 23, 2020·The International Journal of Neuroscience·Khosro JamebozorgiAmirhossein Sahebkar
Mar 5, 2020·Molecular Biology Reports·Carmela Rita BalistreriAlexander Vaiserman
Jan 21, 2017·The New Phytologist·Md Shakhawat HossainGary Stacey
May 8, 2013·Molecular Biology Reports·Branka GrškovićGordan Mršić
Sep 5, 2018·Breast Cancer Research : BCR·Holly HollidayAlexander Swarbrick
Jul 26, 2017·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Arron Munggela FomaMahdi Mahmoudi
Feb 17, 2021·Epigenetics : Official Journal of the DNA Methylation Society·Lauren Y M MiddletonKelly M Bakulski
May 11, 2020·Life Sciences·Armita Mahdavi GorabiAmirhossein Sahebkar
Apr 19, 2021·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Wenlong WangHideko Sone

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Methods Mentioned

BETA
RNA-Seq
immunoprecipitation
chip
ChIP-Seq
Methyl-Seq
xenograft
deamination

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