DNA Methylation in Inflammatory Pathways Modifies the Association between BMI and Adult-Onset Non-Atopic Asthma.

International Journal of Environmental Research and Public Health
Ayoung JeongNicole Probst-Hensch

Abstract

A high body mass (BMI) index has repeatedly been associated with non-atopic asthma, but the biological mechanism linking obesity to asthma is still poorly understood. We aimed to test the hypothesis that inflammation and/or innate immunity plays a role in the obesity-asthma link. DNA methylome was measured in blood samples of 61 non-atopic participants with asthma and 146 non-atopic participants without asthma (non-smokers for at least 10 years) taking part in the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) study. Modification by DNA methylation of the association of BMI or BMI change over 10 years with adult-onset asthma was examined at each CpG site and differentially methylated region. Pathway enrichment tests were conducted for genes in a priori curated inflammatory pathways and the NLRP3-IL1B-IL17 axis. The latter was chosen on the basis of previous work in mice. Inflammatory pathways including glucocorticoid/PPAR signaling (p = 0.0023), MAPK signaling (p = 0.013), NF-κB signaling (p = 0.031), and PI3K/AKT signaling (p = 0.031) were enriched for the effect modification of BMI, while NLRP3-IL1B-IL17 axis was enriched for the effect modification of BMI change over 10 years (p = 0.046)...Continue Reading

References

Aug 27, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Takayoshi SuganamiYoshihiro Ogawa
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aravind SubramanianJill P Mesirov
Oct 8, 2005·The American Journal of Clinical Nutrition·Anne B NewmanTamara B Harris
May 2, 2006·Statistical Applications in Genetics and Molecular Biology·Mark J van der LaanAlan E Hubbard
Jan 20, 2007·American Journal of Respiratory and Critical Care Medicine·David A Beuther, E Rand Sutherland
Apr 15, 2008·The Journal of Allergy and Clinical Immunology·Stephanie A Shore
May 16, 2008·American Journal of Respiratory and Critical Care Medicine·Pranab HaldarRuth H Green
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
Feb 7, 2009·The European Respiratory Journal·F Castro-GinerN M Probst-Hensch
Sep 3, 2009·Molecular and Cellular Endocrinology·Sandra GalicGregory R Steinberg
Nov 7, 2009·American Journal of Respiratory and Critical Care Medicine·Wendy C MooreUNKNOWN National Heart, Lung, and Blood Institute's Severe Asthma Research Program
Jan 11, 2011·Nature Medicine·Bolormaa VandanmagsarVishwa Deep Dixit
Jun 28, 2011·Nature Genetics·Kasper Daniel HansenAndrew P Feinberg
May 10, 2012·BMC Bioinformatics·Eugene Andres HousemanKarl T Kelsey
Jul 19, 2012·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R V FengerA Linneberg
Jan 15, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Yi-an ChenRosanna Weksberg
Feb 7, 2013·Environmental Health Perspectives·Dennie G A J HebelsUNKNOWN EnviroGenomarkers Project Consortium
Mar 12, 2013·Nucleic Acids Research·Timothy J TricheKimberly D Siegmund
May 7, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Xiaojing XuXiaoling Wang
Jul 17, 2013·Scientific Reports·Deepa RastogiJohn M Greally
Mar 19, 2014·Lancet·Katherine J DickNilesh J Samani
Apr 17, 2014·Thorax·Joerg SteierJohn Moxham
Jun 14, 2014·The European Respiratory Journal·Anders Lindén, Barbro Dahlén
Aug 26, 2014·Epigenetics : Official Journal of the DNA Methylation Society·Lakshitha P GunawardhanaKatherine J Baines
Dec 22, 2014·The Journal of Allergy and Clinical Immunology·Francesco AnnunziatoSergio Romagnani
May 15, 2015·Epigenetics & Chromatin·Timothy J PetersPeter L Molloy
Jun 2, 2015·Statistical Applications in Genetics and Molecular Biology·Konstantina Charmpi, Bernard Ycart
Jul 15, 2015·BMC Bioinformatics·Dongmei LiTimothy Dye
Jan 19, 2016·Frontiers in Immunology·Angela CastoldiPedro M Moraes-Vieira
Aug 28, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Adam J SantanastoAnne B Newman
Mar 28, 2017·Respiratory Medicine·Ayoung JeongNicole Probst-Hensch
Feb 17, 2018·Nuclear Receptor Research·Asoka BannoRaju C Reddy
Mar 3, 2018·The Lancet. Respiratory Medicine·Cheng-Jian XuGerard H Koppelman
Dec 24, 2018·The Journal of Allergy and Clinical Immunology·Sarah E ReeseStephanie J London
Dec 26, 2018·The Lancet. Respiratory Medicine·Erick FornoJuan C Celedón

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Citations

Apr 8, 2020·American Journal of Respiratory and Critical Care Medicine·Deepa RastogiJohn M Greally
Jul 2, 2019·Environmental Research·Sergi Sayols-BaixerasRoberto Elosua
Apr 8, 2020·Paediatric Respiratory Reviews·Laura ChenDeepa Rastogi
Mar 28, 2021·Clinical Immunology : the Official Journal of the Clinical Immunology Society·José J Leija-MartínezFengyang Huang
Mar 31, 2021·Clinical Epigenetics·Mojgan SheikhpourVahid Amiri
Dec 19, 2021·Current Allergy and Asthma Reports·Varun Sharma, Douglas C Cowan

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Methods Mentioned

BETA
blood draw
chips
chip

Software Mentioned

DAVID
GSEA
R package DMRcate
GSEA ( set enrichment analysis
IPA
R package “ minfi ”

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