DNA Methylation in Major Depressive Disorder

Advances in Experimental Medicine and Biology
Ehsan PishvaDaniel van den Hove

Abstract

Epigenetic mechanisms regulate gene expression, influencing protein levels and ultimately shaping phenotypes during life. However, both stochastic epigenetic variations and environmental reprogramming of the epigenome might influence neurodevelopment and ageing, and this may contribute to the origins of mental ill-health. Studying the role of epigenetic mechanisms is challenging, as genotype-, tissue- and cell type-dependent epigenetic changes have to be taken into account, while the nature of mental disorders also poses significant challenges for linking them with biological profiles. In this chapter, we summarise the current evidence suggesting the role of DNA methylation as a key epigenetic mechanism in major depressive disorder.

Citations

Oct 3, 2017·British Journal of Pharmacology·Sarra G Bahna, Lennard P Niles
Aug 11, 2019·CNS & Neurological Disorders Drug Targets·Divya GoelShaikh Aamer
May 11, 2018·Stem Cells International·Hang ZhouYongxiang Wang
Oct 6, 2020·Frontiers in Cell and Developmental Biology·Qiuyue XuBin Yuan
Jun 30, 2018·Molecular Psychiatry·Gabor EgervariYasmin L Hurd
May 7, 2020·Depression Research and Treatment·Monika Talarowska
Oct 27, 2020·Frontiers in Psychiatry·Zhenghao Duan, Jie Lu

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