DNA methylation in personalized medicine

Personalized Medicine
Muhammad A BudimanJared M Ordway

Abstract

The importance of epigenetics in normal development and tissue-specific gene expression, as well as in diseases such as cancer, is well established. DNA methylation is a primary epigenetic modification that is directly linked to the genome itself. Here, we review evidence supporting the promise of DNA methylation-based biomarkers in personalized medicine, discuss standard and emerging technologies for profiling DNA methylation on a genome-wide scale, and forecast how these approaches will be used in parallel to better understand the epigenetics of health and disease and apply that knowledge to advance the field of personalized medicine.

References

Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M FrommerC L Paul
Oct 11, 1983·Nucleic Acids Research·M A Gama-SosaM Ehrlich
Jan 1, 1993·Cold Spring Harbor Symposia on Quantitative Biology·S M TilghmanS Zemel
Apr 22, 1993·Nature·S RainierA P Feinberg
Aug 1, 1997·Trends in Genetics : TIG·J A YoderT H Bestor
Dec 23, 1999·Current Opinion in Genetics & Development·A F Smit
Jan 19, 2000·Nature·B D Strahl, C D Allis
Apr 18, 2000·Mutation Research·A E Pegg
May 2, 2000·Journal of Molecular Biology·F J StewartE A Raleigh
May 18, 2001·Biochemical and Biophysical Research Communications·T SakataniM Oshimura
Mar 15, 2003·Science·Hengmi CuiAndrew P Feinberg
Oct 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yuzuru Shiio, Robert N Eisenman
Mar 5, 2004·Journal of the National Cancer Institute·Karen WoodsonPhillip Schoenfeld
Jul 23, 2004·Nature·Zachary LippmanRob Martienssen
Aug 4, 2004·Genes & Development·Konrad HochedlingerRudolf Jaenisch
Mar 11, 2005·The New England Journal of Medicine·Monika E HegiRoger Stupp
Jul 12, 2005·Nature Genetics·Min HuKornelia Polyak
Jul 19, 2005·Laboratory Investigation; a Journal of Technical Methods and Pathology·Tibor Rauch, Gerd P Pfeifer
Sep 17, 2005·Nature Methods·Zachary LippmanRob Martienssen
Dec 17, 2005·Cancer Research·Atsushi Kaneda, Andrew P Feinberg
Dec 21, 2005·Genome Research·Robert A RollinsTimothy H Bestor
Dec 22, 2005·Nature Reviews. Genetics·Andrew P FeinbergSteven Henikoff
Jan 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Serge SaxonovDouglas L Brutlag
Jan 31, 2006·Nature Genetics·Ilana KeshetItamar Simon
Jul 1, 2006·Genome Research·Batbayar KhulanJohn M Greally
Jul 11, 2006·Nucleic Acids Research·Claudia GebhardMichael Rehli
Aug 9, 2006·Nucleic Acids Research·Helle F JørgensenAdrian P Bird
Oct 17, 2006·Nucleic Acids Research·Ashraf E K IbrahimJames D Brenton
Dec 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Atsushi KanedaAndrew P Feinberg
Dec 20, 2007·PloS One·Jared M OrdwayJeffrey A Jeddeloh
Dec 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Tibor A RauchGerd P Pfeifer
Mar 5, 2008·Genome Research·Rafael A IrizarryAndrew P Feinberg
Jul 10, 2008·Nature Biotechnology·Thomas A DownStephan Beck
Oct 7, 2008·The International Journal of Biochemistry & Cell Biology·Sònia Guil, Manel Esteller
Nov 7, 2008·Methods in Molecular Biology·Tibor A Rauch, Gerd P Pfeifer

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Citations

Nov 1, 2011·Personalized Medicine·Leander Van NesteJames S Clark
Jul 1, 2013·Personalized Medicine·Ruth Chadwick, Alan O'Connor

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Methods Mentioned

BETA
sumoylation
methylation profiling
PCR
affinity capture
deamination

Software Mentioned

MethylScope

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