DNA Methylation in Schizophrenia

Advances in Experimental Medicine and Biology
Lotta-Katrin PriesGunter Kenis

Abstract

Schizophrenia is a highly heritable psychiatric condition that displays a complex phenotype. A multitude of genetic susceptibility loci have now been identified, but these fail to explain the high heritability estimates of schizophrenia. In addition, epidemiologically relevant environmental risk factors for schizophrenia may lead to permanent changes in brain function. In conjunction with genetic liability, these environmental risk factors-likely through epigenetic mechanisms-may give rise to schizophrenia, a clinical syndrome characterized by florid psychotic symptoms and moderate to severe cognitive impairment. These pathophysiological features point to the involvement of epigenetic processes. Recently, a wave of studies examining aberrant DNA modifications in schizophrenia was published. This chapter aims to comprehensively review the current findings, from both candidate gene studies and genome-wide approaches, on DNA methylation changes in schizophrenia.

Citations

Feb 8, 2019·Reviews in the Neurosciences·Tomasz BielawskiDorota Frydecka
Nov 12, 2019·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Lotta-Katrin PriesBart P F Rutten
Aug 11, 2019·CNS & Neurological Disorders Drug Targets·Divya GoelShaikh Aamer
Jun 21, 2020·Translational Psychiatry·Paula RoviraMarta Ribasés
Jun 30, 2018·Molecular Psychiatry·Gabor EgervariYasmin L Hurd
Nov 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Magdalena GórnyElżbieta Lorenc-Koci
May 23, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·Allan Radaic, Daniel Martins-de-Souza
Nov 24, 2021·Journal of Molecular Neuroscience : MN·Omran DavarinejadYazdan Rahmati

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