DNA methylation in the developing hippocampus and amygdala of anxiety-prone versus risk-taking rats.

Developmental Neuroscience
Rebecca K SimmonsSarah M Clinton

Abstract

All organisms exhibit a wide range of emotional behaviors and interact with the environment in different ways. Some individuals may be more quiet and shy whereas others are more outgoing and adventurous. These temperamental and personality differences can predispose individuals to certain psychopathologies which may be influenced by genetic vulnerability and/or early life experiences. Rodent models can be used to recapitulate emotional reactivity differences, and these models can, in turn, be used to examine potential neurobiological underpinnings of these traits. The present study utilizes two strains of rats that were selectively bred for differences in novelty seeking. High Novelty-Responding (bHR) rats are very active in response to novelty, exhibit exaggerated risk-taking, aggression, impulsivity, and show increased behavioral response to cocaine. Low Novelty-Responding (bLR) rats show increased anxiety, depressive behavior and vulnerability to chronic stress. One way in which the bHR versus bLR behavioral phenotypes may differ is through epigenetic modification of DNA. DNA can be modified through processes such as acetylation or methylation to either enhance or subdue gene expression. This study examines putative differen...Continue Reading

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Citations

Aug 21, 2013·Brain Research·Rebecca K SimmonsSarah M Clinton
Oct 15, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Jennifer Blaze, Tania L Roth
Apr 10, 2013·Epigenomics·Richard G Hunter, Bruce S McEwen
Apr 30, 2015·Addiction Biology·Samantha L WhiteMathieu E Wimmer
Jul 1, 2014·Neuroscience·B B Griffiths, R G Hunter
Dec 25, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Gretha J BoersmaKellie L Tamashiro
May 28, 2013·Journal of Psychiatric Research·Adriana MedinaStanley J Watson
Jun 25, 2020·Environmental and Molecular Mutagenesis·Nicole M WannerChristopher Faulk
Jul 23, 2019·Progress in Neuro-psychopharmacology & Biological Psychiatry·Chelsea R McCoySarah M Clinton
Feb 12, 2021·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Sarah M ClintonMatthew E Glover
Mar 16, 2021·Frontiers in Neuroscience·Hector Bravo-RiveraGregory J Quirk
May 4, 2021·Reviews in the Neurosciences·Annamaria SrancikovaJan Bakos

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