DNA Methylation Inhibitors in Cancer Therapy: The Immunity Dimension

Cell
Jonathan D Licht

Abstract

DNA demethylating agents are approved for some blood malignancies and are under active investigation in solid tumors, but how these drugs work has remained unclear. In this issue of Cell, two groups show that these agents activate a toxic cellular antiviral program through transcriptional activation of endogenous retroviral sequences.

References

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Citations

Jan 23, 2016·Journal of Medicinal Chemistry·Vineet Pande
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