DNA Methylation is Correlated with Pluripotency of Stem Cells

Current Stem Cell Research & Therapy
Ruofeng Wang, Tianqing Li


Pluripotency of stem cells is an important scientific issue and is attracting great interest for the broader community, especially for regenerative medicine field. Pluripotent stem cells (PSCs) in mammalians are defined as naive- and primed-states according to their cellular, molecular, epigenetic and functional states. Understand the correlation between DNA methylation and pluripotency of stem cells. Based on published papers, we discussed the DNA methylation and corresponding functions for embryonic stem cells. We also summarized the correlation between DNA methylation and naive state maintenance, and outlook future emphasis of DNA methylation for primate naive PSCs. DNA methylation is closely associated with cell reprogramming, functional remodeling and cell differentiation of PSCs. The pluripotency and naive characteristics of PSCs are closely associated with cell DNA methylation. However, the mechanisms, which are involved in methylation modifications of naive ground, are still one of the important scientific issues for primate naive PSCs because of lack of widely accepted culture condition.


Jan 17, 2020·Development·Jihong YangJianlong Wang

Related Concepts

DNA Methylation [PE]
Regenerative Medicine
Pluripotent Stem Cells
Protein Methylation
DNA Methylation
Nerve Regeneration
Cell Differentiation Process
Study of Epigenetics
Cellular Reprogramming

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