DNA Methylation is Correlated with Pluripotency of Stem Cells

Current Stem Cell Research & Therapy
Ruofeng Wang, Tianqing Li

Abstract

Pluripotency of stem cells is an important scientific issue and is attracting great interest for the broader community, especially for regenerative medicine field. Pluripotent stem cells (PSCs) in mammalians are defined as naive- and primed-states according to their cellular, molecular, epigenetic and functional states. Understand the correlation between DNA methylation and pluripotency of stem cells. Based on published papers, we discussed the DNA methylation and corresponding functions for embryonic stem cells. We also summarized the correlation between DNA methylation and naive state maintenance, and outlook future emphasis of DNA methylation for primate naive PSCs. DNA methylation is closely associated with cell reprogramming, functional remodeling and cell differentiation of PSCs. The pluripotency and naive characteristics of PSCs are closely associated with cell DNA methylation. However, the mechanisms, which are involved in methylation modifications of naive ground, are still one of the important scientific issues for primate naive PSCs because of lack of widely accepted culture condition.

References

Jan 17, 2020·Development·Jihong YangJianlong Wang

Related Concepts

DNA Methylation [PE]
Regenerative Medicine
Pluripotent Stem Cells
Medicine
Protein Methylation
DNA Methylation
Nerve Regeneration
Cell Differentiation Process
Study of Epigenetics
Cellular Reprogramming

Related Feeds

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

Genetics & Epigenetics
Jifang XiaoLiangqi Xie
Human Molecular Genetics
Lingyi Chen, George Q Daley
Seikagaku. The Journal of Japanese Biochemical Society
Shinya Yamanaka
Advances in Experimental Medicine and Biology
Eleni M Tomazou, Alexander Meissner
© 2020 Meta ULC. All rights reserved