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DNA methylation modulates transcription factor occupancy chiefly at sites of high intrinsic cell-type variability

bioRxiv

Feb 27, 2014

Matthew T. MauranoJohn A. Stamatoyannopoulos

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Abstract

The nuclear genome of every cell harbors millions of unoccupied transcription factor (TF) recognition sequences that harbor methylated cytosines. Although DNA methylation is commonly invoked as a repressive mechanism, the extent to which it actively silences specific TF occupancy sites ...read more

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Landscapes
Transcription Factor Binding
Chromatin
DNMT1 gene
Genome
CTCF gene
Patterns
Site
DNA Modification Methylases
Methylate
13
26
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  • DNA methylation modulates transcription factor occupancy chiefly at sites of high intrinsic cell-type variability

    bioRxiv

    Feb 27, 2014

    Matthew T. MauranoJohn A. Stamatoyannopoulos

    PMID: 990003061

    DOI: 10.1101/003061

    Abstract

    The nuclear genome of every cell harbors millions of unoccupied transcription factor (TF) recognition sequences that harbor methylated cytosines. Although DNA methylation is commonly invoked as a repressive mechanism, the extent to which it actively silences specific TF occupancy sites ...read more

    Mentioned in this Paper

    Landscapes
    Transcription Factor Binding
    Chromatin
    DNMT1 gene
    Genome
    13
    26

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