Abstract
Dickkopf-related protein 3 (DKK3) gene, as a tumor suppressor gene, has been discovered in various cancers, but its relationship with tumor chemoresistance is still unclear. In this study, this laboratory detected that DNA methylation contributes to the downregulation of DKK3 in docetaxel resistance of human lung cancer cells and its possible biochemical mechanism. DKK3 has been proved to be downregulated by hypermethylation in docetaxel-resistant lung cancer cells. Upregulation of DKK3 can reverse the chemoresistance of docetaxel-resistant cell lines in vitro by growth inhibition and enhancement of apoptosis. Conversely, downregulation of DKK3 could induce parental human lung cancer cells insensitivity to docetaxel by promoting proliferative capacity and inhibiting apoptosis of cancer cells. In addition, the authors observed that overexpression of DKK3 might decrease the expression of P-glycoprotein. All results suggested that epigenetic downregulation of DKK3 leads to docetaxel resistance in human nonsmall cell lung cancer (NSCLC) cells by increased expression of P-glycoprotein. DKK3 may reveal a novel molecular target for docetaxel resistance for NSCLC patients in the future.
References
Feb 22, 2007·Oncogene·J StaubV Shridhar
Dec 1, 2007·Carcinogenesis·Wen YueLin Zhang
Sep 16, 2009·Carcinogenesis·Shikhar SharmaPeter A Jones
Nov 11, 2009·Journal of Cellular and Molecular Medicine·Wang RuiChen Long-Bang
Mar 2, 2010·Cytoskeleton·Luis J Leandro-GarcíaCristina Rodríguez-Antona
Jul 30, 2010·The Journal of Obstetrics and Gynaecology Research·Tao JiangShulan Zhang
Oct 5, 2010·Nature Reviews. Drug Discovery·Charles Dumontet, Mary Ann Jordan
Jan 27, 2011·Molecular Carcinogenesis·Koji UenoRajvir Dahiya
Nov 11, 2011·Journal of Translational Medicine·Christoph ZenzmaierPeter Berger
Nov 29, 2011·Cancer Letters·Bing FengLong-Bang Chen
Dec 6, 2011·Cancer·Bing FengLong-Bang Chen
Jul 19, 2012·IUBMB Life·Hyun-Jung ChoiYoung-Guen Kwon
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Feb 2, 2013·Current Cancer Drug Targets·Ziyad Binkhathlan, Afsaneh Lavasanifar
Apr 9, 2013·Molecular Cancer Research : MCR·Shi-Yun CuiWei De
May 3, 2013·Molecular Cancer Therapeutics·Sucharita J Mistry, William K Oh
Jun 7, 2013·Drug Metabolism and Drug Interactions·Nicolás González-VacarezzaAdrián Llerena
Jul 19, 2013·Molecular Cancer Therapeutics·Yezi ZhuAllen C Gao
Jul 28, 2013·Biochemical Pharmacology·Isabel Marzo, Javier Naval
Jul 31, 2013·Journal of Cellular and Molecular Medicine·Tingxiu XiangQian Tao
Sep 4, 2013·Nature Reviews. Clinical Oncology·Elizabeth A KuczynskiRobert S Kerbel
Jan 28, 2014·Anti-cancer Drugs·Monika JoshiChandra P Belani
Mar 29, 2014·Molecular Medicine Reports·Chang-Cheng GuoJun-Hua Zheng
Citations
Sep 16, 2015·Molecular Oncology·Stephanie N DormanPeter K Rogan
Apr 21, 2016·Toxicology and Applied Pharmacology·Timothy N PerkinsNiki L Reynaert
Jun 18, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Keqian ZhangZhe Wang
Oct 28, 2016·Oncotarget·Yihua PeiHuiqin Zhuo
Sep 12, 2019·Communications Biology·Nusrat J EpsiAntonina Mitrofanova
Jul 20, 2016·Molecular Medicine Reports·Yanmei XuTingguo Zhang
Dec 10, 2016·Frontiers in Oncology·Tom G KeulersKasper M A Rouschop
May 31, 2018·Cancers·Hoda KardooniRobert M Kypta
Aug 28, 2020·Frontiers in Oncology·Susana Romero-GarciaAngeles Carlos-Reyes
Dec 2, 2020·Angewandte Chemie·Vedagopuram SreekanthAvinash Bajaj
Jan 12, 2020·Communications Biology·Nusrat J EpsiAntonina Mitrofanova
Jul 14, 2021·Biochemical Genetics·Yan-Yan Chen, Ying-Chun Tai