DNA methylation of hepatitis B virus (HBV) genome associated with the development of hepatocellular carcinoma and occult HBV infection

The Journal of Infectious Diseases
Pushpinder KaurZdenko Herceg

Abstract

Recent studies have identified the presence of methylation in the hepatitis B virus (HBV) genome and have suggested that it may be an important mechanism regulating transcription and replication of the HBV virus. However, it remains unclear whether this phenomenon is associated with occult hepatitis. Here, we performed a detailed analysis of DNA methylation in the HBV genome in liver samples of patients at different stages of hepatocarcinoma development and in in vitro infected hepatocytes and found discrete CpG sites in the HBV genome that are recurrently hypermethylated in cancer but not in chronic hepatitis tissue.

Citations

Jul 26, 2012·Seminars in Immunopathology·Giovanni RaimondoTeresa Pollicino
Jan 11, 2012·Clinical Microbiology Reviews·Jasmine SamalPerumal Vivekanandan
Mar 2, 2013·PloS One·Yongmei ZhangJiming Zhang
May 31, 2014·World Journal of Gastroenterology : WJG·Teresa Pollicino, Carlo Saitta
Nov 21, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ji-Cai ZhangHai-Ping Li
Apr 11, 2014·Viruses·Jaime Morales-RomeroRebeca García-Román
Jan 19, 2016·Frontiers in Microbiology·Lemonica Koumbi, Peter Karayiannis
Jan 21, 2014·Journal of Viral Hepatitis·X Huang, F B Hollinger
Aug 29, 2014·Journal of Medical Virology·Eleanor A PowellJason T Blackard
Jun 12, 2016·Trends in Microbiology·Chiaho ShihRen-Shiang Jhou
Jan 1, 2012·Pharmaceuticals·Victor V Levenson, Anatoliy A Melnikov
Apr 13, 2018·Genes·Kristie BloomPatrick Arbuthnot
Jan 24, 2019·Cellular and Molecular Life Sciences : CMLS·Dmitry KostyushevVladimir Chulanov
Apr 8, 2015·World Journal of Hepatology·Dong Hee SeoKyou Sup Han
Jan 13, 2016·Archiv der Pharmazie·Amr M El-ArabyMoustafa E El-Araby
Apr 8, 2016·World Journal of Gastroenterology : WJG·Hui-Lan ZhuZhen-Hua Zhang
Dec 30, 2014·World Journal of Hepatology·Min-Sun Kwak, Yoon Jun Kim
Jun 25, 2021·World Journal of Gastroenterology : WJG·Prashika SinghKristie Bloom
Jun 13, 2018·ACS Infectious Diseases·Jin HuJu-Tao Guo

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