DNA methylation of the NR3C1 promoter region in brains of pediatric victims of physical abuse

Neurocase
Yoichiro TakahashiYoshihiko Kominato

Abstract

Early life stress (ELS) has been suggested to cause epigenetic changes to genes in the brain, such as the Nuclear Receptor Subfamily 3, Group C, Member 1 gene (NR3C1). Conversely, evaluation of the epigenetic status in the postmortem brain might provide clues to the antemortem ELS experience. We examined DNA methylation of the 1F promoter region of NR3C1 in the postmortem brains of eight children including four ELS cases. As a result, DNA methylation was evident in ELS cases due to severe physical abuse. Epigenetic status may have potential application as a biomarker for clarifying the antemortem experiences of deceased.

References

Apr 8, 1988·Cell·H Cedar
Dec 1, 1994·The Journal of Pediatrics·A LevineZ Zadik
Jun 29, 2004·Nature Neuroscience·Ian C G WeaverMichael J Meaney
Jul 5, 2006·Pediatrics·Kent P HymelUNKNOWN National Association of Medical Examiners
Feb 24, 2009·Nature Neuroscience·Patrick O McGowanMichael J Meaney
Jun 28, 2011·Pediatrics and Neonatology·Ming-Chi Lai, Li-Tung Huang
Mar 8, 2012·Epigenetics : Official Journal of the DNA Methylation Society·Elizabeth A Mazzio, Karam F A Soliman

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Citations

Jun 19, 2021·Neurobiology of Stress·Pascal IbrahimGustavo Turecki
Jun 26, 2021·The European Journal of Neuroscience·Jacqueline S WomersleySîan M J Hemmings

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Methods Mentioned

BETA
PCR

Software Mentioned

ELS

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