DNA methylation of the promoter region of bnip3 and bnip3l genes induced by metabolic programming

BMC Genomics
Vincent VeronIban Seiliez

Abstract

Environmental changes of biotic or abiotic nature during critical periods of early development may exert a profound influence on physiological functions later in life. This process, named developmental programming can also be driven through parental nutrition. At molecular level, epigenetic modifications are the most likely candidate for persistent modulation of genes expression in later life. In order to investigate epigenetic modifications induced by programming in rainbow trout, we focused on bnip3 and bnip3l paralogous genes known to be sensitive to environmental changes but also regulated by epigenetic modifications. Two specific stimuli were used: (i) early acute hypoxia applied at embryo stage and (ii) broodstock and fry methionine deficient diet, considering methionine as one of the main methyl-group donor needed for DNA methylation. We observed a programming effect of hypoxia with an increase of bnip3a and the four paralogs of bnip3l expression level in fry. In addition, parental methionine nutrition was correlated to bnip3a and bnip3lb1 expression showing evidence for early fry programming. We highlighted that both stimuli modified DNA methylation levels at some specific loci of bnip3a and bnip3lb1. Overall, these dat...Continue Reading

References

Mar 21, 1998·The Journal of Nutrition·A Lucas
Nov 30, 1998·Science·A AmoresJ H Postlethwait
Aug 2, 2000·Proceedings of the National Academy of Sciences of the United States of America·R K Bruick
Jan 10, 2002·Genes & Development·Adrian Bird
Nov 9, 2002·Bioinformatics·Long-Cheng Li, Rajvir Dahiya
Mar 6, 2003·Genome Research·John S TaylorYves Van de Peer
Mar 12, 2004·Molecular Biology and Evolution·Alan ChristoffelsByrappa Venkatesh
Aug 4, 2004·Cancer Research·Jiro OkamiCraig D Logsdon
Dec 21, 2004·Cancer Cell·Peiwen FeiWafik S El-Deiry
Feb 17, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·I GeurdenS Panserat
Sep 7, 2007·Cancer Metastasis Reviews·Howard R Mellor, Adrian L Harris
Feb 19, 2008·The Journal of Biological Chemistry·Huafeng ZhangGregg L Semenza
Mar 6, 2009·The American Journal of Clinical Nutrition·Steven H Zeisel
Apr 21, 2009·FEBS Letters·Robert S Illingworth, Adrian P Bird
Sep 30, 2009·Nature Reviews. Endocrinology·Michael E SymondsHelen Budge
Apr 27, 2010·Annual Review of Nutrition·Graham C Burdge, Karen A Lillycrop
Apr 16, 2011·Bioinformatics·Derek W BarnettGabor T Marth
Dec 14, 2011·Molecular and Cellular Endocrinology·Lawrence P Reynolds, Joel S Caton
Jan 5, 2012·Nature Reviews. Genetics·Robert Feil, Mario F Fraga
Jan 27, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lindsey A GeorgeStephen P Ford
Mar 6, 2012·Nature Methods·Ben Langmead, Steven L Salzberg
Jun 25, 2013·Trends in Endocrinology and Metabolism : TEM·Daniella E Duque-Guimarães, Susan E Ozanne
Oct 9, 2013·Critical Reviews in Biochemistry and Molecular Biology·Veronica L DenglerJoaquín M Espinosa
Oct 18, 2013·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Aug 7, 2014·Molecular Biology Reports·Nagarjuna Vasagiri, Vijay Kumar Kutala
Feb 10, 2016·Endocrinology·Vasantha PadmanabhanMuraly Puttabyatappa

❮ Previous
Next ❯

Citations

Dec 4, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Erick PereraJaume Pérez-Sánchez
Nov 15, 2020·Fish Physiology and Biochemistry·Erick PereraJaume Pérez-Sánchez

❮ Previous
Next ❯

Methods Mentioned

BETA
ChIP
PCR

Software Mentioned

Ensembl
BAM
BiQ Analyzer HT
R
BLAST
NGS QC Toolkit
R Commander Package
Bowtie 2
MethPrimer
Genomicus

Related Concepts

Related Feeds

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.