DNA Methylation Patterns in the Round Goby Hypothalamus Support an On-The-Spot Decision Scenario for Territorial Behavior

Vincent SomervilleIrene Adrian-Kalchhauser


The question as to how early life experiences are stored on a molecular level and affect traits later in life is highly topical in ecology, medicine, and epigenetics. In this study, we use a fish model to investigate whether DNA methylation mediates early life experiences and predetermines a territorial male reproductive phenotype. In fish, adult reproductive phenotypes frequently depend on previous life experiences and are often associated with distinct morphological traits. DNA methylation is an epigenetic mechanism which is both sensitive to environmental conditions and stably inherited across cell divisions. We therefore investigate early life predisposition in the round goby Neogobius melanostomus by growth back-calculations and then study DNA methylation by MBD-Seq in the brain region controlling vertebrate reproductive behavior, the hypothalamus. We find a link between the territorial reproductive phenotype and high growth rates in the first year of life. However, hypothalamic DNA methylation patterns reflect the current behavioral status independently of early life experiences. Together, our data suggest a non-predetermination scenario in the round goby, in which indeterminate males progress to a non-territorial status ...Continue Reading


Jan 10, 2002·Genes & Development·Adrian Bird
Jul 2, 2002·Reproduction : the Official Journal of the Society for the Study of Fertility·B P SetchellE M Ritzen
Jul 28, 2005·Hormones and Behavior·Rui F OliveiraDavid Gonçalves
Aug 10, 2005·Proceedings. Biological Sciences·Nadia Aubin-HorthH A Hofmann
Dec 6, 2005·Nucleic Acids Research·Daniel J WeisenbergerPeter W Laird
Mar 8, 2008·Physiology & Behavior·M ScantleburyN C Bennett
May 1, 2008·Nucleic Acids Research·Stefan GötzAna Conesa
May 17, 2008·Comparative and Functional Genomics·Leng Han, Zhongming Zhao
Sep 9, 2008·The Journal of Experimental Biology·Susan C P RennH A Hofmann
Oct 15, 2008·Annual Review of Pharmacology and Toxicology·Moshe Szyf
Feb 24, 2009·Nature Neuroscience·Patrick O McGowanMichael J Meaney
Apr 28, 2009·General and Comparative Endocrinology·Yonathan ZoharOlivier Kah
Jun 10, 2009·Bioinformatics·Heng Li1000 Genome Project Data Processing Subgroup
Jan 19, 2010·Current Biology : CB·Sarah E HallPiali Sengupta
Jan 29, 2010·Genome Research·Shinji MaegawaJean-Pierre J Issa
Jan 30, 2010·Bioinformatics·Aaron R Quinlan, Ira M Hall
Feb 2, 2010·Brain Research·Yoshiko KuroyanagiHideaki Takeuchi
Feb 10, 2010·Nature Reviews. Genetics·Julie A Law, Steven E Jacobsen
Apr 17, 2010·Biological Reviews of the Cambridge Philosophical Society·Caitlin M Dmitriew
Jul 20, 2010·The Journal of Animal Ecology·Jeffrey S Shima, Stephen E Swearer
Feb 1, 1996·Trends in Ecology & Evolution·M R Gross
Feb 1, 2011·Bioinformatics·Robert Schmieder, Robert Edwards
Mar 11, 2011·Annals of the New York Academy of Sciences·Yossy MachlufGil Levkowitz
Jun 1, 2006·Integrative and Comparative Biology·Jan A Pechenik
Oct 11, 2011·BMC Genetics·Paloma Morán, Andrés Pérez-Figueroa
Mar 6, 2012·Nature Methods·Ben Langmead, Steven L Salzberg
May 12, 2012·Oncotarget·Daudi JjingoI King Jordan
Feb 13, 2013·Nature Reviews. Genetics·Zachary D Smith, Alexander Meissner
Jan 31, 2014·Evolutionary Applications·Philipp E HirschJasminca Behrmann-Godel
Mar 19, 2014·Genes & Development·Karyn L SheafferKlaus H Kaestner
Mar 25, 2014·G3 : Genes - Genomes - Genetics·David M McGaugheyLawrence C Brody
Apr 12, 2014·Frontiers in Endocrinology·Md ShahjahanIshwar S Parhar
Aug 6, 2014·Molecular Genetics and Genomics : MGG·Stella M K Glasauer, Stephan C F Neuhauss
Oct 18, 2014·Frontiers in Genetics·Paulino MartínezFrancesc Piferrer
Oct 31, 2014·Genome Biology and Evolution·Ning JiangZewei Luo
Nov 29, 2014·BMC Genomics·Alexandra WeyrichJoerns Fickel
Jan 9, 2015·The Journal of Experimental Biology·Sara D CardosoRui F Oliveira
Sep 8, 2016·Clinical Epigenetics·Fleur A D LeenenJonathan D Turner
Mar 30, 2017·Cell Reports·Renchao ChenYi Zhang
Oct 14, 2017·Ecology Letters·Christina L RichardsKoen J F Verhoeven
Jan 20, 2019·Nature Communications·Sara A GrimmPaul A Wade


Dec 28, 2019·Genes·Christoph GrunauDominique Joly
Jan 30, 2020·BMC Biology·Irene Adrian-KalchhauserSylke Winkler

Related Concepts

Cell Division
Pharmaceutical Preparations
Hypothalamic Structure
Bleomycin/Cisplatin/Methotrexate Protocol
Round Shape
DNA Methylation

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.