DNA methylation patterns of LINE-1 and Alu for pre-symptomatic dementia in type 2 diabetes

PloS One
Chanachai Sae-LeeHyang-Min Byun

Abstract

The identification of early markers of dementia is important for higher-risk populations such as those with type 2 diabetes (T2D). Retrotransposons, including long interspersed nuclear element 1 (LINE-1) and Alu, comprise ~40% of the human genome. Although dysregulation of these retrotransposons can induce aberrant gene regulation and genomic instability, their role in the development of pre-symptomatic dementia (PSD) among T2D patients is unknown. Here, we examined locus-specific changes in LINE-1 and Alu methylation in PSD and the potential to offset these changes via supplementation with folate and vitamin B12. We interrogated DNA methylation patterns corresponding to 22,352 probes for LINE-1 and Alu elements using publicly-available Illumina Infinium 450K methylation datasets from i) an 18-month prospective study in 28 T2D patients (GSE62003) and ii) an intervention study in which 44 individuals were supplemented with folic acid (400 μg/day) and vitamin B12 (500 μg/day) over two years (GSE74548). We identified 714 differentially methylated positions (DMP) mapping to retrotransposons in T2D patients who developed PSD in comparison to those who did not (PFDR < 0.05), comprised of 2.4% (228 probes) of all LINE-1 probes and 3.8...Continue Reading

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Citations

Jun 5, 2021·Epigenetics & Chromatin·Xena Giada Pappalardo, Viviana Barra
Oct 7, 2021·Human Cell·Márcia Rodrigues Amorim, Marcelo Aguiar Costa Lima
Oct 17, 2021·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Qinglin SunJunchao Duan

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Methods Mentioned

BETA
RNA-seq

Software Mentioned

Over Representation Analys
R Studio
RepeatMasker
WebGestalt ( WEB - based
SPSS
Gene SeT AnaLysis Toolkit )

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