DNA methylation profiles of CpG islands for cellular differentiation and development in mammals

Cytogenetic and Genome Research
K Shiota

Abstract

DNA methylation has been implicated in mammalian development. Transcription units contain CpG islands, but expression of CpG island associated genes in normal tissues was not believed to be controlled by DNA methylation. There are, however, numerous CpG islands containing tissue-dependent and differentially methylated regions (T-DMR), which are potential methylation sites in normal cells and tissues. Genomic scanning which focused on T-DMRs in CpG islands revealed that the DNA methylation profile of each cell/tissue is more complicated than previously considered. Differentiation of cells is associated with both methylation and demethylation, which occur at multiple loci. The epigenetic system characterized by DNA methylation requires cells to memorize gene expression patterns, thus, standardizing cellular phenotypes.

Citations

Dec 24, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Koji HayakawaKunio Shiota
Feb 5, 2010·Pharmaceutical Research·Sayaka IchiharaYuichi Sugiyama
Oct 31, 2006·Nature Genetics·Florian EckhardtStephan Beck
Mar 21, 2008·Proceedings of the National Academy of Sciences of the United States of America·Mathias EhrichDirk van den Boom
Oct 3, 2007·Cloning and Stem Cells·Sho SendaKunio Shiota
Aug 15, 2008·Molecular Human Reproduction·Hiromi AsadaNorihiro Sugino
Feb 17, 2009·Molecular Human Reproduction·Yoshiaki YamagataNorihiro Sugino
Apr 16, 2013·Nucleic Acids Research·Hala AbdouniMani Larijani
Sep 3, 2010·Pharmacogenetics and Genomics·Vadim YuferovMary Jeanne Kreek
May 24, 2006·Cytogenetic and Genome Research·J D LiebJ M Greally
Apr 23, 2009·BMC Bioinformatics·Christopher PrevitiCoral del Val
May 25, 2011·The Journal of Reproduction and Development·Shun SatoKunio Shiota
May 25, 2011·The Journal of Reproduction and Development·Yoshikazu AraiKunio Shiota
Jun 21, 2011·The Journal of Reproduction and Development·Ryo MaekawaKunio Shiota
Feb 14, 2006·The Journal of Reproduction and Development·Maksym KremenskoyKunio Shiota
Feb 14, 2006·The Journal of Reproduction and Development·Maksym KremenskoyKunio Shiota
Jan 25, 2012·International Journal of Molecular Sciences·Shahram GolbabapourMaryam Hajrezaei
Apr 12, 2014·Genes·Elisavet A PapageorgiouPhilippos C Patsalis
Feb 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Fei SongWilliam A Held
Jun 22, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Hua RenK H Andy Choo
Feb 15, 2014·Critical Reviews in Biochemistry and Molecular Biology·Krithika VaidyanathanLance Wells
Jun 18, 2010·Kidney International·Ryota KikuchiKunio Shiota
Mar 14, 2009·Microscopy Research and Technique·Jean-Pierre Dadoune
Dec 14, 2007·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Masako SuzukiKunio Shiota

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.