DNA methylation status defines clinicopathological parameters including survival for patients with clear cell renal cell carcinoma (ccRCC)

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Emma Andersson EvelönnGöran Roos

Abstract

Epigenetic alterations in the methylome have been associated with tumor development and progression in renal cell carcinoma (RCC). In this study, 45 tumor samples, 12 tumor-free kidney cortex tissues, and 24 peripheral blood samples from patients with clear cell RCC (ccRCC) were analyzed by genome-wide promoter-directed methylation arrays and related to clinicopathological parameters. Unsupervised hierarchical clustering separated the tumors into two distinct methylation groups (clusters A and B), where cluster B had higher average methylation and increased number of hypermethylated CpG sites (CpGs). Furthermore, tumors in cluster B had, compared with cluster A, a larger tumor diameter (p = 0.033), a higher morphologic grade (p < 0.001), a higher tumor-node-metastasis (TNM) stage (p < 0.001), and a worse prognosis (p = 0.005). Higher TNM stage was correlated to an increase in average methylation level (p = 0.003) and number of hypermethylated CpGs (p = 0.003), whereas a number of hypomethylated CpGs were mainly unchanged. However, the predicted age of the tumors based on methylation profile did not correlate with TNM stage, morphological grade, or methylation cluster. Differently methylated (DM) genes (n = 840) in ccRCC samples...Continue Reading

References

Oct 1, 1982·The American Journal of Surgical Pathology·S A FuhrmanC Limas
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·J G HermanW M Linehan
Jun 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Essel DulaimiPaul Cairns
Dec 6, 2005·Nucleic Acids Research·Daniel J WeisenbergerPeter W Laird
Feb 3, 2006·International Journal of Cancer. Journal International Du Cancer·Eri AraiSetsuo Hirohashi
Mar 4, 2008·Cancer Treatment Reviews·Kiran GuptaClaudie Charbonneau
Mar 14, 2008·The New England Journal of Medicine·Manel Esteller
Jul 16, 2008·International Journal of Cancer. Journal International Du Cancer·Nina WagenerFelix Hoppe-Seyler
Nov 26, 2008·Molecular Cell·Raphael MargueronDanny Reinberg
Sep 8, 2010·Genome Medicine·Mark R Morris, Eamonn R Maher
Jan 21, 2011·Nature·Raphaël Margueron, Danny Reinberg
Mar 21, 2012·Epigenetics : Official Journal of the DNA Methylation Society·Christopher J RickettsEamonn R Maher
Nov 28, 2012·Molecular Cell·Gregory HannumKang Zhang
Jan 1, 2011·Expert Opinion on Medical Diagnostics·Sofia HalinAnders Bergh
Oct 22, 2013·Genome Biology·Steve Horvath
Mar 4, 2014·PloS One·Rose K LaiJill Barnholtz-Sloan
Apr 15, 2014·ISRN Gastroenterology·Jiaqiu LiXian Wang
Jul 6, 2014·Applied Immunohistochemistry & Molecular Morphology : AIMM·Linda KöhnGöran Roos
Jul 30, 2014·Neoplasia : an International Journal for Oncology Research·Sofie DegermanGöran Roos
Aug 16, 2014·Biochemical and Biophysical Research Communications·Timothy M Barrow, Karin B Michels
Oct 11, 2014·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Wolfgang WagnerQiong Lin
Apr 17, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yong WangDan Yue
May 15, 2015·Genome Biology·Steve Horvath

❮ Previous
Next ❯

Citations

Aug 6, 2020·Clinical and Experimental Pharmacology & Physiology·Yi MiaoPeijun Liu
Jan 5, 2020·Insights Into Imaging·Roberto Lo GulloKatja Pinker
Jan 16, 2019·BMC Cancer·Emma Andersson EvelönnSofie Degerman
May 20, 2018·Molecular Diagnosis & Therapy·Brittany N Lasseigne, James D Brooks

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Epigenetics & Methyl-CpG (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. Here is the latest research on cancer epigenetics and methyl-CpG binding proteins including ZBTB38.

Adenocarcinoma, Clear Cell

Clear Cell Adenocarcinoma is a tumor that arises in the female genital tract and is characterized by cells that appear clear under the microscope. Discover the latest research here.

Cancer Epigenetics

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.