DNA Methylation Targets Influenced by Bisphenol A and/or Genistein Are Associated with Survival Outcomes in Breast Cancer Patients.

Genes
Rohit R JadhavCoral A Lamartiniere

Abstract

Early postnatal exposures to Bisphenol A (BPA) and genistein (GEN) have been reported to predispose for and against mammary cancer, respectively, in adult rats. Since the changes in cancer susceptibility occurs in the absence of the original chemical exposure, we have investigated the potential of epigenetics to account for these changes. DNA methylation studies reveal that prepubertal BPA exposure alters signaling pathways that contribute to carcinogenesis. Prepubertal exposure to GEN and BPA + GEN revealed pathways involved in maintenance of cellular function, indicating that the presence of GEN either reduces or counters some of the alterations caused by the carcinogenic properties of BPA. We subsequently evaluated the potential of epigenetic changes in the rat mammary tissues to predict survival in breast cancer patients via the Cancer Genomic Atlas (TCGA). We identified 12 genes that showed strong predictive values for long-term survival in estrogen receptor positive patients. Importantly, two genes associated with improved long term survival, HPSE and RPS9, were identified to be hypomethylated in mammary glands of rats exposed prepuberally to GEN or to GEN + BPA respectively, reinforcing the suggested cancer suppressive p...Continue Reading

References

Nov 17, 1993·Journal of the National Cancer Institute·R G ZieglerM B Hyer
May 1, 1996·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M FukutakeK Wakabayashi
Jul 1, 1998·Environmental Health Perspectives·J S Colt, A Blair
Dec 16, 1998·The American Journal of Clinical Nutrition·C A LamartiniereM S Cotroneo
Dec 16, 1998·The American Journal of Clinical Nutrition·K D SetchellJ E Heubi
Dec 22, 1998·Molecular and Cellular Biology·J M GudasS Coats
Sep 1, 1999·British Journal of Cancer·L Hilakivi-ClarkeR Clarke
Mar 7, 2002·The Journal of Nutrition·Coral A LamartiniereAda Elgavish
Aug 22, 2002·Carcinogenesis·Anna H WuMalcolm C Pike
Apr 6, 2006·Journal of the National Cancer Institute·Bruce J TrockRobert Clarke
Aug 15, 2006·Chemosphere·Ryoko Kuruto-NiwaRyushi Nozawa
Nov 18, 2006·Cancer Causes & Control : CCC·Joanne ThanosLilian U Thompson
Nov 25, 2006·Reproductive Toxicology·Gail S PrinsShuk-Mei Ho
Sep 11, 2007·Reproductive Toxicology·Laura N VandenbergWade V Welshons
Jan 17, 2008·Environmental Health Perspectives·Antonia M CalafatLarry L Needham
Sep 23, 2008·Biochemical and Biophysical Research Communications·Takeshi YaoiShinji Fushiki
Mar 10, 2009·Environmental Health Perspectives·Elizabeth W LapenseeNira Ben-Jonathan
Mar 26, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Larissa A KordeRegina G Ziegler
Jul 11, 2009·Environmental Health Perspectives·Sarah JenkinsCoral A Lamartiniere
Jun 21, 2011·Hormone Molecular Biology and Clinical Investigation·Coral A LamartiniereJose Russo
Jul 7, 2011·The Journal of Steroid Biochemistry and Molecular Biology·Sarah JenkinsCoral A Lamartiniere
Apr 3, 2012·Environmental and Molecular Mutagenesis·Olivia S AndersonDana C Dolinoy
Sep 25, 2012·Nature·UNKNOWN Cancer Genome Atlas Network
Feb 5, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Habibul AhsanAlice S Whittemore
Oct 17, 2014·Nutrients·Maria PudenzClarissa Gerhauser
Jan 15, 2015·Cancer Biomarkers : Section a of Disease Markers·Haiyan ZhengJianqiao Liu

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Citations

Jan 13, 2018·Genes·Xiaolong Cheng, Victor X Jin
Jan 18, 2020·Environmental Health Perspectives·Felicia Fei-Lei Chung, Zdenko Herceg
Sep 15, 2020·Critical Reviews in Toxicology·Akin Cayir
Apr 30, 2020·Environmental Science and Pollution Research International·Michael J WilliamsHelgi B Schiöth
Mar 19, 2020·Nutrients·Priyanga SelvakumarAshakumary Lakshmikuttyamma
Dec 18, 2020·Frontiers in Nutrition·Barbara J StillwaterOrnella I Selmin
Jan 5, 2021·Environmental Epigenetics·Carolyn F McCabeJaclyn M Goodrich
Jan 29, 2021·Frontiers in Genetics·Tengfei QinXiangFen Xiao
Sep 28, 2020·Environmental Research·Akin CayirTimothy M Barrow
Sep 2, 2021·Critical Reviews in Toxicology·Akin Cayir

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Methods Mentioned

BETA
Cap-Seq
ChIP-seq
MBD-seq
acetylations

Software Mentioned

Illumina
LONUT
Bowtie
Ingenuity
Ingenuity Pathway Analysis
QIAGEN

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