DNA methylation/hydroxymethylation in melanoma

Oncotarget
Siqi FuQianjin Lu

Abstract

Melanoma is a malignant tumor of melanocytes and is considered to be the most aggressive cancer among all skin diseases. The pathogenesis of melanoma has not been well documented, which may restrict the research and development of biomarkers and therapies. To date, several genetic and epigenetic factors have been identified as contributing to the development and progression of melanoma. Besides the findings on genetic susceptibilities, the recent progress in epigenetic studies has revealed that loss of the DNA hydroxymethylation mark, 5-hydroxymethylcytosine (5-hmC), along with high levels of DNA methylation at promoter regions of several tumor suppressor genes in melanoma, may serve as biomarkers for melanoma. Moreover, 5-Aza-2'-deoxycytidine, an epigenetic modifier causing DNA demethylation, and ten-eleven translocation family dioxygenase (TET), which catalyzes the generation of 5-hmC, demonstrate therapeutic potential in melanoma treatment. In this review, we will summarize the latest progress in research on DNA methylation/hydroxymethylation in melanoma, and we will discuss and provide insight for epigenetic biomarkers and therapies for melanoma. Particularly, we will discuss the role of DNA hydroxymethylation in melanoma i...Continue Reading

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Citations

Jan 9, 2019·Journal of Cellular Physiology·Mohammad Hossein PourhanifehZatollah Asemi
Jan 30, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Benjamin V BeckerReinhard Ullmann
Jun 11, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Yun HuangAiguo Ren
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Feb 6, 2020·Genes, Chromosomes & Cancer·Catarina SalgadoRemco van Doorn
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Mar 30, 2021·OncoTargets and Therapy·Sangiliyandi GurunathanJin-Hoi Kim
Jun 12, 2018·Pharmacology & Therapeutics·Melina MitsiogianniMihalis I Panayiotidis
Jul 3, 2021·Dermatopathology·Alexandre StahlAlexandre Moulin
Aug 28, 2021·Diagnostics·Antonios RevythisStergios Boussios

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