DNA methyltransferase Dnmt1 and mismatch repair

Oncogene
Keh-Yang Wang, C-K James Shen

Abstract

We have examined the relationship between DNA mismatch repair and deficiency of DNA methylation in a mouse embryonic cell line, Dnmt1-/- ES, with homologous deletion of the gene coding for the maintenance DNA methyltransferase Dnmt1. With the use of a sensitive PCR for the assay of two mononucleotide- and three dinucleotide microsatellite markers that exhibited instabilities in mismatch repair-deficient cells, significantly higher frequencies of instability were detected at three of the five markers in Dnmt1-/- ES than the wild-type ES. The data suggest that Dnmt1 enzyme plays an integrating role in DNA replication and/or repair. The implication that Dnmt1 enzyme and/or cytosine methylation may participate in the strand discrimination of mismatch repair during eukaryotic DNA replication is discussed.

References

Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J HolmesP Modrich
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J T Hare, J H Taylor
Apr 21, 1972·Nature·W G Bradley, T A Papapetropoulos
May 5, 1995·Science·R ParsonsB Vogelstein
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·N P BhattacharyyaM Meuth
Oct 1, 1995·Trends in Biochemical Sciences·R D Kolodner
Jan 1, 1996·Annual Review of Biochemistry·P Modrich, R Lahue
Sep 17, 1998·Nature·R Z ChenR Jaenisch
Nov 21, 1998·The EMBO Journal·J Jiricny
Nov 6, 2002·Proceedings of the National Academy of Sciences of the United States of America·Edmund WongWinfried Edelmann
Jan 28, 2003·Cell Cycle·Paula M VertinoLinda H Malkas
Apr 19, 2003·Science·Amir EdenRudolf Jaenisch
Nov 26, 2003·Molecular Carcinogenesis·Omar KabbarahPaul J Goodfellow
Dec 18, 2003·The Journal of Clinical Investigation·Lorne J HofsethCurtis C Harris
Nov 1, 1943·Genetics·S E Luria, M Delbrück

❮ Previous
Next ❯

Citations

Dec 7, 2007·Cell and Tissue Research·Tom LathamBernard Ramsahoye
Feb 9, 2006·Chemical Reviews·Ravi R IyerPaul L Modrich
Mar 23, 2011·Oligonucleotides·R Geoffrey SargentDieter C Gruenert
Feb 7, 2008·Human Molecular Genetics·Vincent DionJohn H Wilson
Mar 21, 2007·Molecular and Cellular Biology·Marc Damelin, Timothy H Bestor
Jul 1, 2006·Molecular and Cellular Biology·Maloy GhoshMichael Leffak
Oct 13, 2009·Yi chuan = Hereditas·Zhi-Gang Wang, Jian-Xin Wu
Jun 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Oliver MortusewiczHeinrich Leonhardt
Sep 20, 2011·Clinical Epigenetics·Emily L Putiri, Keith D Robertson
Dec 23, 2009·Progress in Biophysics and Molecular Biology·Denis Michel
Jul 19, 2015·Journal of Molecular Cell Biology·Ning DingHeather M O'Hagan
Jun 23, 2012·Epigenetics : Official Journal of the DNA Methylation Society·Christine A ArmstrongCristina Tufarelli
Apr 6, 2005·Human Molecular Genetics·Peter W Laird
Oct 5, 2016·Reviews on Environmental Health·Meredith EcksteinYvonne Fondufe-Mittendorf
Apr 3, 2021·Seminars in Cancer Biology·Wesley N Saintilnord, Yvonne Fondufe-Mittendorf
Oct 27, 2005·Molecular Cancer·Alfonso Dueñas-GonzálezEduardo Cervera

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.