DNA-microarray analysis of brain cancer: molecular classification for therapy

Nature Reviews. Neuroscience
Paul S MischelStanley F Nelson

Abstract

Primary brain tumours are among the most lethal of all cancers, largely as a result of their lack of responsiveness to current therapy. Numerous new therapies hold great promise for the treatment of patients with brain cancer, but the main challenge is to determine which treatment is most likely to benefit an individual patient. DNA-microarray-based technologies, which allow simultaneous analysis of expression of thousands of genes, have already begun to uncover previously unrecognized patient subsets that differ in their survival. Here, we review the progress made so far in using DNA microarrays to optimize brain cancer therapy.

References

Dec 11, 1999·Nature·L H HartwellA W Murray
Jan 6, 2000·Journal of the National Cancer Institute·J M LeglerM S Linet
Mar 4, 2000·Nature Genetics·U ScherfJ N Weinstein
Aug 30, 2000·Nature·C M PerouD Botstein
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·J M AngelastroL A Greene
Oct 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·A J ButteI S Kohane
Oct 18, 2000·Nature·H JeongA L Barabási
Apr 3, 2001·Annual Review of Neuroscience·R Wechsler-Reya, M P Scott
Aug 24, 2001·Nature·S M DhanasekaranA M Chinnaiyan
Sep 13, 2001·Proceedings of the National Academy of Sciences of the United States of America·J E StauntonT R Golub
Sep 13, 2001·Proceedings of the National Academy of Sciences of the United States of America·T SørlieA L Børresen-Dale
Dec 4, 2001·Nature Genetics·Scott A ArmstrongStanley J Korsmeyer
Dec 14, 2001·Proceedings of the National Academy of Sciences of the United States of America·S RamaswamyT R Golub
Mar 14, 2002·Toxicologic Pathology·Gary A BoormanKevin T Morgan
Mar 16, 2002·Journal of Neuropathology and Experimental Neurology·Paul KleihuesWebster K Cavenee
Mar 29, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sridhar Ramaswamy, Todd R Golub
Mar 30, 2002·Nature Biotechnology·Joanne M YeakleyXiang-Dong Fu
May 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rebecca A BetenskyJ Gregory Cairncross
Jun 12, 2002·Molecular Biology of the Cell·Michael L WhitfieldDavid Botstein
Jun 21, 2002·The New England Journal of Medicine·Andreas RosenwaldUNKNOWN Lymphoma/Leukemia Molecular Profiling Project
Jul 3, 2002·Nature Reviews. Cancer·Igor Vivanco, Charles L Sawyers
Aug 31, 2002·Science·David M BermanPhilip A Beachy
Dec 18, 2002·Physical Review Letters·Himanshu Agrawal
Dec 20, 2002·The New England Journal of Medicine·Marc J van de VijverRené Bernards
Feb 7, 2003·Proceedings of the National Academy of Sciences of the United States of America·Sean P BohenRonald Levy
Feb 13, 2003·Journal of Neuropathology and Experimental Neurology·Guido Reifenberger, David N Louis
Feb 13, 2003·Brain Pathology·Paul S Mischel, Timothy F Cloughesy
Mar 1, 2003·Proceedings of the National Academy of Sciences of the United States of America·Ingrid HedenfalkJeffrey Trent
Apr 18, 2003·Oncogene·Paul S MischelStanley F Nelson
May 3, 2003·Cancer Cell·Lance A LiottaEmanuel F Petricoin
Jun 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Trudy G OliverRobert J Wechsler-Reya
Jun 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Therese SorlieDavid Botstein
Jul 19, 2003·Neoplasia : an International Journal for Oncology Research·Ganesh RaoDaniel W Fults

❮ Previous
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Citations

Dec 6, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Andreas H JacobsPedro Lowenstein
Sep 5, 2006·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Mandeep S TamberJames T Rutka
Feb 8, 2007·Journal of Neuro-oncology·Carlos A ScrideliLuiz G Tone
May 4, 2005·Current Neurology and Neuroscience Reports·Santosh KesariPatrick Y Wen
Feb 9, 2006·Current Oncology Reports·Santosh KesariPatrick Y Wen
Apr 3, 2009·Chemical Reviews·Philip J Tofilon, Kevin Camphausen
Jan 31, 2007·Journal of the American Chemical Society·Ryan C BaileyJames R Heath
Oct 16, 2009·Nature·Daniel H Geschwind, Genevieve Konopka
Aug 26, 2006·Nature Clinical Practice. Neurology·Giovanni Coppola, Daniel H Geschwind
Jul 19, 2005·Nature Reviews. Neuroscience·Wolfgang Löscher, Heidrun Potschka
Dec 29, 2012·Bioinformatics·Liming WangMichael S Samoilov
Aug 24, 2011·Molecular Cancer Therapeutics·Koppany VisnyeiHarley I Kornblum
Aug 9, 2008·PloS One·Mieke SchuttePim J French
Feb 8, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jeremy A MillerDaniel H Geschwind
Apr 5, 2007·Paediatric Drugs·Iacopo SardiMaura Massimino
Oct 1, 2008·Biomarkers in Medicine·Sabine ClassenJoachim L Schultze
Jan 2, 2010·Neurosurgical Focus·Paul A NorthcottMichael D Taylor
Jun 22, 2006·Future Oncology·Ruty Mehrian-Shai, Juergen K V Reichardt
Sep 15, 2006·Proceedings of the National Academy of Sciences of the United States of America·Masatomo KobayashiKatsuo Furukubo-Tokunaga
Dec 6, 2014·Neuroimaging Clinics of North America·Whitney B Pope
Dec 6, 2014·Neuroimaging Clinics of North America·L Celso Hygino da Cruz, Margareth Kimura
Sep 5, 2009·Neuromolecular Medicine·Joachim SilberJ Graeme Hodgson
Oct 22, 2005·Nature Reviews. Cancer·Joseph A Ludwig, John N Weinstein
Sep 28, 2010·Neuro-Chirurgie·D Fontaine, P Paquis

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