DNA microarray-based analysis of single nucleotide polymorphisms may be useful for assessing the risks and benefits of hormone therapy

Fertility and Sterility
Clemens B TempferAxel Muendlein

Abstract

To determine what percentage of women can be given individualized counseling based on genetic information, as single nucleotide polymorphisms (SNPs) are associated with risks and benefits of estrogen therapy and hormone therapy such as thrombosis, myocardial infarction, breast cancer, and bone protection. Cross-sectional study. Academic research institution. A consecutive series of 2,507 perimenopausal and postmenopausal women. Peripheral venous puncture and multiplex polymerase chain reaction on a microarray system. Analysis of 22 SNPs of 17 genes: AGTMet235Thr, APOECys112Arg, APOEArg158Cys, COMTVal158Met, CYP17-34T>C, CYP191558C>T, CYP19Arg264Cys, CYP1A16235T>C, CYP1A1Ile462Val, CYP1B1Leu432Val, CYP1B1Asn453Ser, HSD17B1-27A>C, ER-alphaIVS-401T>C, prothrombin20210G>A, factor V Leiden, eNOS-786T>C, eNOSGlu298Asp, MRSer810Leu, MTHFR677C>T, PAI 15G>4G, SRD5A2Val89Leu, and VDRb>B. Among the women in the study, 66% had at least two homozygous mutant SNPs of interest. A thrombophilic disposition was found in 9.9% of women, and 23% of women had at least two SNPs associated with an increased risk of breast cancer (COMT, CYP17, CYP19, CYP1A1, and CYP1B1). The SNPs predisposing women to cardiovascular pathologies (e.g., APOE, AGT, eNOS,...Continue Reading

References

Jan 7, 2000·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H W DengR R Recker
Mar 14, 2000·Oncogene·V N KristensenA L Børresen-Dale
Aug 24, 2000·The New England Journal of Medicine·D M HerringtonD Waters
Dec 29, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T SalménP H Mäenpää
Mar 17, 2001·JAMA : the Journal of the American Medical Association·B M PsatyF R Rosendaal
Jul 9, 2002·The Breast Journal·Yasuo MiyoshiShinzaburo Noguchi
Jul 19, 2002·JAMA : the Journal of the American Medical Association·Jacques E RossouwUNKNOWN Writing Group for the Women's Health Initiative Investigators

❮ Previous
Next ❯

Citations

Jun 30, 2006·Breast Cancer Research and Treatment·Jose Luis RoyoLuis Miguel Real
Jan 8, 2010·Breast Cancer Research and Treatment·Konstantinos P Economopoulos, Theodoros N Sergentanis
Jun 27, 2008·Pharmacological Reviews·Virginia M Miller, Sue P Duckles
Oct 6, 2010·Hypertension·Virginia M Miller
Oct 5, 2010·Women's Health·V M Miller
Sep 9, 2008·Fertility and Sterility·Sena Erdogan AydosKaan Aydos
Nov 15, 2007·Reproductive Sciences·Eva-Katrin BentzClemens B Tempfer
Aug 2, 2007·Obstetrics and Gynecology·Felix StonekClemens B Tempfer
Mar 4, 2006·Disasters·Laurens M Bouwer, Jeroen C J H Aerts
Aug 24, 2006·Expert Review of Anticancer Therapy·Mehdi Nassiri, Mehrdad Nadji
Mar 1, 2006·Expert Review of Endocrinology & Metabolism·Johannes C Huber, Clemens B Tempfer

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.