DNA mismatch repair and cancer

Current Opinion in Cell Biology
T A Prolla

Abstract

Mutations in DNA mismatch repair (MMR) genes have been associated with hereditary nonpolyposis colorectal cancer. Studies in bacteria, yeast and mammals suggest that the basic components of the MMR system are evolutionarily conserved, but studies in eukaryotes also imply novel functions for MMR proteins. Recent results suggest that mutations in MMR genes lead to tumorigenesis in mice, but DNA replication errors appear to be insufficient to initiate intestinal tumorigenesis in this model system. Additionally, MMR-deficient cell lines display a mutator phenotype and resistance to several cytotoxic agents, including compounds widely used in cancer chemotherapy.

References

Nov 11, 1976·Proceedings of the National Academy of Sciences of the United States of America·R Wagner, M Meselson
Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·B O Parker, M G Marinus
Sep 1, 1990·Mutation Research·M GrilleyP Modrich
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·S S Su, P Modrich
Jan 1, 1983·Molecular & General Genetics : MGG·I D HicksonP T Emmerson
Apr 29, 1982·Nature·P Karran, M G Marinus
Oct 24, 1995·Proceedings of the National Academy of Sciences of the United States of America·M StrandT D Petes
Jun 30, 1995·Science·N PapadopoulosK W Kinzler
Mar 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·G M Li, P Modrich
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·T A KunkelK A Johnson
Mar 5, 1993·Science·A Sancar, J E Hearst
May 7, 1993·Science·L A AaltonenS R Hamilton
Nov 1, 1995·Human Molecular Genetics·N P BhattacharyyaM Meuth
Feb 15, 1996·Genes & Development·G T MarsischkyR Kolodner
Jun 28, 1996·Cell·W EdelmannR Kucherlapati
Feb 1, 1996·Seminars in Cancer Biology·P Karran
Aug 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·J HuangM G Dunlop

❮ Previous
Next ❯

Citations

Aug 31, 2002·Genes, Chromosomes & Cancer·Elena KolomietzJeremy A Squire
Aug 1, 2000·Mutation Research·J C Game
Oct 26, 1999·Immunology Today·C A ReynaudJ C Weill
Mar 20, 2002·Biochimie·Sandrine Jacob, Françoise Praz
Apr 8, 2000·Current Opinion in Genetics & Development·P Karran
Apr 12, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Paloma MartinCarmen Bellas
Apr 20, 2001·The New England Journal of Medicine·T WatanabeS R Hamilton
Feb 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hideki ShimodairaJean Y J Wang
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·C T McMurray
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·K DrotschmannT A Kunkel
Jul 14, 2004·Nucleic Acids Research·Xiufen LeiLuZhe Sun
Feb 15, 2011·Biomedical and Environmental Sciences : BES·Shi-Ying LiZi-Chun Hua
Apr 22, 2004·Clinical Genetics·P HudlerR Komel
Feb 26, 2000·Annual Review of Genetics·A B BuermeyerR M Liskay
Mar 21, 2000·Genesis : the Journal of Genetics and Development·D L Pittman, J C Schimenti
May 13, 2017·Briefings in Bioinformatics·Igor B RogozinDavid N Cooper
Oct 11, 2001·British Journal of Cancer·A S SolimanS R Hamilton
Jan 16, 1999·Nucleic Acids Research·A B ClarkT A Kunkel
May 4, 2021·Frontiers in Oncology·Qinglian HeWei Zhu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.