DNA mismatch repair system. Classical and fresh roles

The FEBS Journal
Sung-Hoon JunChangill Ban

Abstract

The molecular mechanisms of the DNA mismatch repair (MMR) system have been uncovered over the last decade, especially in prokaryotes. The results obtained for prokaryotic MMR proteins have provided a framework for the study of the MMR system in eukaryotic organisms, such as yeast, mouse and human, because the functions of MMR proteins have been conserved during evolution from bacteria to humans. However, mutations in eukaryotic MMR genes result in pleiotropic phenotypes in addition to MMR defects, suggesting that eukaryotic MMR proteins have evolved to gain more diverse and specific roles in multicellular organisms. Here, we summarize recent advances in the understanding of both prokaryotic and eukaryotic MMR systems and describe various new functions of MMR proteins that have been intensively researched during the last few years, including DNA damage surveillance and diversification of antibodies.

References

Nov 11, 1976·Proceedings of the National Academy of Sciences of the United States of America·R Wagner, M Meselson
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J HolmesP Modrich
Dec 1, 1972·Genetics·E C CoxM L Scheppe
Apr 14, 1983·Nature·S Tonegawa
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A KatP Modrich
Mar 5, 1993·Science·A Sancar, J E Hearst
Feb 15, 1996·Genes & Development·G T MarsischkyR Kolodner
May 1, 1996·Genes & Development·L J Ko, C Prives
Jun 15, 1996·Genes & Development·R Kolodner
Apr 18, 1997·The Journal of Biological Chemistry·M J LongleyP Modrich
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·D R DuckettP Modrich
Nov 28, 2000·Annual Review of Genetics·B D Harfe, S Jinks-Robertson
Jun 7, 2001·Proceedings of the National Academy of Sciences of the United States of America·V BurdettP Modrich
Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·P T TranR M Liskay
Jan 26, 2002·The Journal of Biological Chemistry·Jochen GenschelPaul Modrich

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Citations

Feb 6, 2008·Cell and Tissue Research·Marcelo C LealRüdiger W Schulz
Dec 25, 2007·Cell Research·Wei Yang
Sep 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ivana Marinovic-TerzicJean Y J Wang
Feb 3, 2011·The Journal of Biological Chemistry·Navjotsingh PablaZheng Dong
Jan 22, 2008·Antioxidants & Redox Signaling·Fabio AltieriSilvia Chichiarelli
Mar 31, 2009·Journal of Bacteriology·Vyacheslav Palchevskiy, Steven E Finkel
May 14, 2009·PLoS Genetics·Stéphanie ToméGeneviève Gourdon
Oct 17, 2012·PloS One·Rebecka L BournSanjay I Bidichandani
Jun 28, 2012·World Journal of Gastrointestinal Pathophysiology·Samar HassenParimal Chowdhury
Jun 28, 2014·PloS One·Vahid EzzatizadehMark A Pook
Jan 27, 2012·Pathology Oncology Research : POR·Gabriella LivideFrancesca Ariani
May 1, 2008·Systems Biology in Reproductive Medicine·Matthew L SandersonDouglas T Carrell
Jan 23, 2016·DNA Repair·Flora S Groothuizen, Titia K Sixma
Jan 17, 2016·The Journal of Heredity·Alejandra LandauAlberto R Prina
Mar 15, 2013·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yan-Xia ZhangShu-Yang Xie
Jul 30, 2010·Mutation Research·Yaroslava Y Polosina, Claire G Cupples
Jul 25, 2015·Reproductive Biomedicine Online·Sezgin GunesAshok Agarwal
Jan 7, 2011·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Patrícia Carlos CaldeiraMaria Auxiliadora Vieira do Carmo
Oct 26, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Patrícia Carlos CaldeiraMaria Auxiliadora Vieira do Carmo
Feb 26, 2010·The New Phytologist·Alexandre Maréchal, Normand Brisson
Dec 3, 2009·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Yaroslava Y Polosina, Claire G Cupples
Oct 22, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jen-Chung KoYun-Wei Lin
Nov 16, 2010·Molecular and Biochemical Parasitology·Priscila C CamposSantuza M R Teixeira
Jul 31, 2013·Journal of Magnetic Resonance·Chun Kit Kwok, Sik Lok Lam
Oct 24, 2007·Biochemical and Biophysical Research Communications·Seong-Dal HeoChangill Ban
Sep 1, 2016·Anais Brasileiros De Dermatologia·Dmitry José de Santana SarmentoÉricka Janine Dantas da Silveira
May 10, 2017·International Journal of Molecular Sciences·Raffaella LiccardoFrancesca Duraturo
Mar 3, 2017·Gastroenterology Research and Practice·Raffaella LiccardoFrancesca Duraturo

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