DNA Nanotechnology-Enabled Interfacial Engineering for Biosensor Development

Annual Review of Analytical Chemistry
Dekai YeChunhai Fan

Abstract

Biosensors represent biomimetic analytical tools for addressing increasing needs in medical diagnosis, environmental monitoring, security, and biodefense. Nevertheless, widespread real-world applications of biosensors remain challenging due to limitations of performance, including sensitivity, specificity, speed, and reproducibility. In this review, we present a DNA nanotechnology-enabled interfacial engineering approach for improving the performance of biosensors. We first introduce the main challenges of the biosensing interfaces, especially under the context of controlling the DNA interfacial assembly. We then summarize recent progress in DNA nanotechnology and efforts to harness DNA nanostructures to engineer various biological interfaces, with a particular focus on the use of framework nucleic acids. We also discuss the implementation of biosensors to detect physiologically relevant nucleic acids, proteins, small molecules, ions, and other biomarkers. This review highlights promising applications of DNA nanotechnology in interfacial engineering for biosensors and related areas.

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Citations

Apr 1, 2018·Angewandte Chemie·Qi LiuChunhai Fan
Jul 10, 2019·Nucleic Acids Research·Arun Richard ChandrasekaranKen Halvorsen
Dec 11, 2019·Genes·Es DarleyMatthew A B Baker
Mar 9, 2020·Topics in Current Chemistry·Jie ChenLihua Wang
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Aug 14, 2019·Scientific Reports·Masoud SoltanRezaeeAmin Farrokhabadi
Jan 4, 2019·Bone Research·Yuxin ZhangYunfeng Lin
Apr 8, 2020·Science China. Life Sciences·Fan LiChunhai Fan
Feb 16, 2021·Nature Reviews. Chemistry·Arun Richard Chandrasekaran
Nov 5, 2020·ACS Applied Materials & Interfaces·Meihua LinFan Xia
Feb 23, 2021·Advanced Nanobiomed Research·David M Smith, Adrian Keller
Jun 5, 2021·Advanced Healthcare Materials·Luyao ShenYonggang Ke
Jun 21, 2021·Biosensors & Bioelectronics·Yunlei XianyuTing Yu
Jul 15, 2021·Advanced Science·Shasha LuXiurong Yang
Jul 14, 2021·Chemical Reviews·Min LiQiang Xia
Apr 27, 2021·Annual Review of Analytical Chemistry·Chao Liu, Jiashu Sun
Jul 19, 2019·ACS Applied Materials & Interfaces·Ling ZhangZisheng Tang
Mar 1, 2019·ACS Applied Materials & Interfaces·Dan ZhuJie Chao
Dec 7, 2018·Analytical Chemistry·Simona RanalloFrancesco Ricci
Aug 28, 2021·Biomedicines·Sedigheh FalahiYvonne Joseph
Dec 27, 2019·Journal of the American Chemical Society·Qian LiChengde Mao
Dec 6, 2018·Journal of the American Chemical Society·Zhilei GeChunhai Fan

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Methods Mentioned

BETA
biosensors
biosensing
biosensor
AFM
atomic force microscopy
PCR
biopsy
chips
chip
enzyme-linked immunosorbent assays

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