DNA nanotubes assembled from tensegrity triangle tiles with circular DNA scaffolds

Nanoscale
Noshin AfshanShou-Jun Xiao

Abstract

Using small circular DNA molecules of different lengths as scaffolds, we successfully synthesised DNA nanotubes consisting of Mao's DNA tensegrity triangle tiles with four-arm junctions (Holliday junctions) at all vertices. Due to the intrinsic curvature of the triangle tile and the consecutive tile alignment, the 2D arrays are organised in the form of nanotubes. Two sized triangle tiles with equilateral side lengths of 1.5 and 2.5 full helical turns are connected by the sticky ended cohesion of a duplex with a length of 2.5 helical turns respectively, and their parallel lozenge tiling lattices were demonstrated by high resolution AFM images, where the former lozenge unit cell has a lattice constant of 13.6 nm, and the latter has a larger lattice constant of 17.0 nm. Modification of the triangle tile with infinitesimal disturbance on side lengths and insertion of one thymine single stranded loop at every vertex resulted in comparably similar nanotubes.

References

Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K J BreslauerL A Marky
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·E F FynanH L Robinson
Sep 5, 1997·Science·F R BlattnerY Shao
Aug 26, 1998·Nature·E WinfreeN C Seeman
Jan 24, 2003·Nature·Nadrian C Seeman
Feb 26, 2004·Journal of the American Chemical Society·Dage LiuChengde Mao
Dec 17, 2004·Journal of the American Chemical Society·James C MitchellAndrew J Turberfield
Apr 14, 2005·Nano Letters·Frederick MathieuNadrian C Seeman
Mar 30, 2006·Journal of the American Chemical Society·Yonggang KeHao Yan
Nov 15, 2008·Science·Matthew O BluntPeter H Beton
Apr 8, 2009·Nature Nanotechnology·Ofer I WilnerItamar Willner
Sep 2, 2009·Nano Letters·Zhen-Gang WangItamar Willner
Apr 20, 2010·Nature Nanotechnology·Damian AckermannMichael Famulok
Dec 3, 2010·Nature Chemistry·Ludwig Bartels
Nov 17, 2011·Nature Communications·Ofer I WilnerItamar Willner
Mar 10, 2012·Physical Review Letters·Stephen WhitelamJuan P Garrahan
Mar 22, 2012·Journal of Molecular Recognition : JMR·Nam NguyenNadrian C Seeman
Jul 5, 2012·Angewandte Chemie·Chuan ZhangChengde Mao
Aug 4, 2012·Future Medicinal Chemistry·Jamie Mallinson, Ian Collins
May 9, 2013·Journal of the American Chemical Society·Fei ZhangHao Yan
Jul 8, 2014·Journal of the American Chemical Society·Hongning ZhengShou-Jun Xiao
Jul 3, 2015·Angewandte Chemie·Jiemin ZhaoChengde Mao
Jul 21, 2015·Nature Nanotechnology·Fei ZhangHao Yan
May 18, 2016·Chembiochem : a European Journal of Chemical Biology·Meng WangShou-Jun Xiao

❮ Previous
Next ❯

Citations

Apr 13, 2018·Chembiochem : a European Journal of Chemical Biology·Xin GuoShou-Jun Xiao
Jan 22, 2019·Organic & Biomolecular Chemistry·Mashooq AliShou-Jun Xiao
Jul 15, 2020·Drug Delivery and Translational Research·Mirza Muhammad Faran Ashraf BaigMuhammad Tayyab Ansari
Jul 22, 2019·Journal of Food and Drug Analysis·Mirza Muhammad Faran Ashraf BaigMuhammad Tayyab Ansari
May 21, 2021·Journal of Pharmaceutical Analysis·Mirza Muhammad Faran Ashraf BaigJahanzeb Mudassir

❮ Previous
Next ❯

Methods Mentioned

BETA
AFM
circular oligonucleotides

Software Mentioned

Seeman

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Organic & Biomolecular Chemistry
Pamela E ConstantinouNadrian C Seeman
Journal of the American Chemical Society
Fei ZhangHao Yan
© 2022 Meta ULC. All rights reserved