DNA nanowire translocation phenomena in nanopores

Biomedical Microdevices
Lei Chen, A T Conlisk

Abstract

One recent application of nanopores is to use them as detectors and analyzers for fast DNA sequencing. To better understand the DNA electrokinetic transport through a nanopore, a hydrodynamic model is developed to investigate the flow field, the resistive forces acting on the DNA, the DNA velocity and the ionic current through the nanopore. The numerical results reveal the relation between the DNA velocity and various parameters such as nanopore surface charge and solution concentration. The model is validated by comparing the numerical results with the experimental data for both DNA velocity and ionic current through the nanopore.

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Citations

Dec 18, 2013·Seminars in Cancer Biology·Catherine ThieblemontMaurilio Ponzoni
Feb 1, 2011·Biomedical Microdevices·Lei Chen, A T Conlisk
Jan 14, 2011·Proceedings. Biological Sciences·P David PollyMikael Fortelius
Mar 15, 2019·Biomicrofluidics·Sandip GhosalHsueh-Chia Chang
Jan 14, 2011·Physical Chemistry Chemical Physics : PCCP·Ye Ai, Shizhi Qian
Dec 18, 2013·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Sebastian GetfertPeter Reimann
Jul 16, 2013·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Sebastian GetfertPeter Reimann

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