PMID: 2546124Jun 26, 1989Paper

DNA nucleotide sequence analysis of the immediate-early gene of pseudorabies virus

Nucleic Acids Research
A K Cheung

Abstract

The complete DNA sequence coding for the immediate-early protein (IE180) of pseudorabies virus was determined. The coding region of IE180 is 4380 nucleotides for 1460 amino acid residues. G+C content of the non-coding portion of the IE gene is 70.3% while the G+C content of the coding portion is considerably higher at 80.1%. Correspondingly, codons consisting mainly of Gs and Cs are favoured. Clusters of amino acid homologies are observed among IE180 of pseudorabies virus, ICP4 of herpes simplex virus type-1 and IE140 of varicella-zoster virus, and are organized similarly in all three polypeptides. Functions exhibited by IE180 are assigned, tentatively, to structural domains of the molecule by analogy to the HSV-1 ICP4 polypeptide.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Feb 1, 1985·The Journal of General Virology·A J Davison, J E Scott
Feb 1, 1986·Analytical Biochemistry·M Hattori, Y Sakaki
Jan 18, 1972·Biochimica Et Biophysica Acta·D L BronsonN Biswal
Jul 1, 1972·Virology·H O LudwigM Benyesh-Melnick
Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·L T FeldmanJ R Nevins
Sep 1, 1983·The Journal of General Virology·A J Davison, N M Wilkie

❮ Previous
Next ❯

Citations

Jan 1, 1991·Comparative Immunology, Microbiology and Infectious Diseases·T C Mettenleiter
Sep 1, 1991·Journal of Virological Methods·J R LokensgardT W Molitor
Dec 1, 1992·The Journal of Cell Biology·I SadlerM C Beckerle
Jun 22, 2007·Journal of Virology·Ruhul H Kuddus, Neal A DeLuca
Sep 13, 2003·Journal of Virology·G DelhonD L Rock
Dec 13, 2003·Journal of Virology·Barbara G KluppLynn W Enquist
Feb 14, 2004·Journal of Virology·Ryan Hagglund, Bernard Roizman
Sep 9, 2005·Microbiology and Molecular Biology Reviews : MMBR·Lisa E PomeranzChristoph J Hengartner
Jul 5, 2001·Proceedings of the National Academy of Sciences of the United States of America·M I Tussié-LunaA L Roy
Apr 17, 2008·The European Journal of Neuroscience·Yukiko TomiokaMasahiko Watanabe
May 26, 2004·Journal of Virological Methods·Chienjin Huang, Ching-Ying Wu
Dec 7, 2005·Veterinary Microbiology·Yannick BlanchardAndré Jestin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.