DNA-platinum interactions in vitro with trans- and cis-Pt(NH3)2Cl2.

Bioinorganic Chemistry
J P Macquet, T Theophanides

Abstract

In the present study the nature and the hydrolysis of DNA-Pt complexes with the platinum compounds, [Pt(dien)Cl]Cl, trans- and cis-Pt(NH3)2Cl2, using potentiometric chloride determinations, have been investigated. The trans-Pt(NH3)2Cl2 and the [Pt(dien)Cl]Cl react with the GC planes at the N7(G) sites, while the cis-Pt(NH3)2Cl2 compound reacts with the GC planes and forms a chelate by using the N7(G) and O6(G) sites. The complex is a specific 1:1 Pt:DNA adduct. The platinum atom in cis-Pt(NH3)2Cl2 liberates both chlorine atoms on chelation. A mechanism for the in vivo antitumor activity of the cis-Pt(NH3)2Cl2 is proposed and the structure activity relationship is discussed.

Citations

Sep 28, 1978·Zeitschrift Für Krebsforschung Und Klinische Onkologie. Cancer Research and Clinical Oncology·H W Thielmann, H Gersbach
Jan 1, 1984·Journal of Cancer Research and Clinical Oncology·B WappesS Seeber
Jan 1, 1990·Cancer Chemotherapy and Pharmacology·B J FosterB Leyland-Jones
Jun 19, 1992·Pharmaceutisch Weekblad. Scientific Edition·T J HodesJ H Beijnen
Aug 18, 1976·Biochimica Et Biophysica Acta·J P Macquet, T Theophanides
May 29, 1981·Biochimica Et Biophysica Acta·J L Butour, J P Macquet
Feb 1, 1993·Mutation Research·Y Uno, M Morita
Feb 1, 1980·International Journal of Radiation Oncology, Biology, Physics·I Szumiel
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J BrouwerJ Reedijk
Nov 8, 2012·Bioinorganic Chemistry and Applications·Fangxing XiaoYi Zheng
Sep 12, 1979·Biochemical and Biophysical Research Communications·P LecointeJ L Butour
May 1, 1984·Biopolymers·D HermannW Guschlbauer
Nov 1, 1979·European Journal of Biochemistry·P K Ganguli, T Theophanides
Sep 1, 1977·European Journal of Biochemistry·J L Butour, J P Macquet
Aug 2, 2017·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·T Theophanides, J Anastassopoulou
Oct 25, 1979·Biochimica Et Biophysica Acta·D HermannW Guschlbauer
Jan 1, 1985·Biochimica Et Biophysica Acta·A L Pinto, S J Lippard
Aug 15, 1978·Analytical Biochemistry·J L Butour, J P Macquet

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.