PMID: 6160370Jan 1, 1980Paper

DNA polymerase III-dependent repair synthesis in response to bleomycin in toluene-treated Escherichia coli

Molecular & General Genetics : MGG
S L RossR E Moses

Abstract

Bleomycin (BLM) is an antitumor drug which interacts with and damages DNA. We have reported a repair response dependent on DNA polymerase I in toluene-treated Escherichia coli. We report here that DNA polymerase III can also catalyze a repair response in toluene-treated E. coli following exposure to BLM. Polymerase III-mediated synthesis differs because it is ATP-dependent, whereas polymerase I-mediated repair synthesis is not. Polymerase III repair synthesis is independent of replicative synthesis, as demonstrated in a polA-, dnaBts strain, or use of Novobiocin to inhibit replication, and replication persists in the presence of repair synthesis. It appears that ATP-dependent repair synthesis in response to BLM is also present in polA+ strains. Repair synthesis does not require the uvrA gene product.

References

Feb 1, 1976·Antimicrobial Agents and Chemotherapy·S L Ross, R E Moses
Jan 1, 1977·Progress in Nucleic Acid Research and Molecular Biology·W E Müller, R K Zahn
Feb 21, 1978·Biochemistry·S L Ross, R E Moses
Jul 11, 1978·Biochemistry·E A SausvilleS B Horwitz
Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A D D'Andrea, W A Haseltine
Dec 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·M TakeshitaH Ohtsubo
Jan 1, 1979·Journal of Bacteriology·S Sharma, R E Moses
Jan 1, 1979·Annual Review of Biochemistry·P C HanawaltC A Smith
Dec 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·M GellertJ Tomizawa
Jan 1, 1975·Annual Review of Biochemistry·L GrossmanI Mahler
Jan 1, 1973·Molecular & General Genetics : MGG·D W Mount, C Kosel
Aug 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·J L CampbellC C Richardson
Aug 22, 1973·Nature: New Biology·D A Youngs, K C Smith
Aug 22, 1973·Nature: New Biology·W MaskerH Shizuya
Mar 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·R C TaitD W Smith
Aug 9, 1974·Nature·R M Olivera, E Bonhoeffer
Oct 1, 1967·Journal of Cellular Physiology·A J Clark
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Oct 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·R E Moses, C C Richardson

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Citations

Jan 30, 1990·Biochimica Et Biophysica Acta·M E Hagensee, R E Moses
Jun 1, 1983·Mutation Research·M M HurtR E Moses
Apr 1, 1991·Biochimie·J Knezević-Vukcević, D Simić
Jan 1, 1981·Journal of Supramolecular Structure and Cellular Biochemistry·M M HurtR E Moses
Oct 1, 1989·Molecular & General Genetics : MGG·M KaaschA Quiñones
Dec 1, 1986·Journal of Bacteriology·M E Hagensee, R E Moses

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