PMID: 2497749May 1, 1989Paper

DNA polymorphism of immunoglobulin kappa confers risk of rheumatoid arthritis

Arthritis and Rheumatism
G Moxley

Abstract

To examine the hypothesis that a hereditary factor linked to the immunoglobulin kappa constant segment (C kappa) contributes to risk of rheumatoid arthritis (RA), white persons with RA were examined for Sac I restriction site polymorphisms. RA patients were more likely to have the 5/5-kb C kappa genotype than white control subjects (relative risk 2.8, P less than 0.02). A subgroup of RA patients who were positive for serum rheumatoid factor had a relative risk of 2.4 (P less than 0.05). The subgroup without serum rheumatoid factor had an even higher relative risk of 9.7 (P less than 0.05). The results suggest that immunoglobulin kappa is an important component in the genetic predisposition toward RA.

References

Apr 20, 1978·The New England Journal of Medicine·P Stastny
May 11, 1987·Nucleic Acids Research·L L FieldT Bech-Hansen
Aug 1, 1987·Annals of the Rheumatic Diseases·D SidebottomA Read
Feb 1, 1987·Journal of Immunogenetics·F R Goñi, B Frangione
Oct 1, 1988·Annals of the Rheumatic Diseases·W OllierA Silman
Jan 1, 1987·Arthritis and Rheumatism·D J WalkerA M Stephenson
Feb 1, 1986·Tissue Antigens·H PayamiC Dostal
Apr 25, 1985·The New England Journal of Medicine·Y KurodaM Yamaguchi
Aug 1, 1985·Annals of the Rheumatic Diseases·P A SandersD M Grennan
Jan 1, 1974·The Journal of Experimental Medicine·H G KunkelJ D Capra
Jul 1, 1970·Annals of the Rheumatic Diseases·J S Lawrence
May 1, 1984·American Journal of Epidemiology·D del JuncoL T Kurland

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Citations

Sep 13, 2003·Immunology and Cell Biology·Caroline Tan SardjonoP Mark Hogarth
Sep 1, 1990·The Journal of Clinical Investigation·J S MillerL B Schwartz
May 3, 1990·The New England Journal of Medicine·E D Harris
May 1, 1992·Annals of Clinical Biochemistry·A HaraldssonG B Stoelinga

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