DNA polymorphisms in the chicken growth hormone gene: response to selection for disease resistance and association with egg production

Animal Genetics
U KuhnleinD Zadworny

Abstract

Analysis of the growth hormone (GH) gene in 12 strains of White Leghorn chickens revealed restriction fragment length polymorphisms (RFLPs) at three MspI sites and at a SacI site. Based on linkage disequilibrium analysis, they gave rise to eight different alleles (i.e. combinations of RFLPs), with five occurring at frequencies above 5% in at least one strain. Pairs of GH-RFLPs were at near maximal linkage disequilibrium, suggesting either a lack of recombination or the presence of selection pressure during evolution of the GH gene. Allele frequencies were determined in 12 non-inbred strains derived from three different genetic bases. These strains had been selected either for an array of egg production traits, resistance to Marek's disease or resistance to avian leukosis. Selection for disease resistance was consistently correlated with an increase in the frequency of one of the alleles. One strain segregated for only two alleles, which differed by three RFLPs. Analysis of variance in this strain indicated that the GH allele co-selected with resistance was associated with a delayed onset of ovulation but a higher persistency of ovulation as age progressed, resulting in an overall increase of egg production by 15% (age at first ...Continue Reading

Citations

Jan 10, 2014·International Journal of Molecular Sciences·Yang ZhangGuohong Chen
Jul 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·H C LiuH H Cheng
Apr 14, 2009·General and Comparative Endocrinology·Dianchang ZhangXinping Xu
Oct 26, 2011·Reproduction in Domestic Animals = Zuchthygiene·Mu-Tzu ChangMu-Chiou Huang
Oct 27, 2004·General and Comparative Endocrinology·S HarveyC Aramburo
Jan 1, 2013·Annual Review of Animal Biosciences·Hans H ChengSusan J Lamont
Sep 21, 2016·International Journal of Molecular Sciences·Xinhua WangJingou Tong
Jun 8, 2001·Experimental Biology and Medicine·S C IpF C Leung
Feb 15, 2020·The Journal of Poultry Science·Sadequllah AhmadiTakeshi Ohkubo

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