PMID: 7515665Mar 1, 1994Paper

DNA rearrangements and altered transcripts of the MLL gene in a human T-ALL cell line Karpas 45 with a t(X;11) (q13;q23) translocation

Genes, Chromosomes & Cancer
N R McCabeM O Diaz

Abstract

Translocations involving chromosome band 11q23 are found in both lymphoid and myeloid leukemias as well as in lymphomas, in these translocations. The chromosomes most frequently involved in reciprocal translocations include chromosomes 4, 6, 9, and 19, and we and others have reported that chromosomes 1, 2, 10, 15, 17, 18, 22, and X are also involved. In the cell line Karpas 45, which has a t(X;11) (q13;q23) translocation, we report here that the MLL gene is rearranged and that there are two altered transcripts of MLL that come from the der(11) chromosome.

References

Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·N R McCabeM O Diaz
Dec 11, 1991·Proceedings of the National Academy of Sciences of the United States of America·S Ziemin-van der PoelJ D Rowley
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B A Mozer, I B Dawid
Jan 15, 1988·Cell·R M Evans, S M Hollenberg

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Citations

Aug 26, 2000·Genes, Chromosomes & Cancer·G CuthbertN Bown
Sep 1, 1995·Genes, Chromosomes & Cancer·D S ChervinskyP D Aplan
Sep 1, 1999·British Journal of Haematology·J F Dimartino, M L Cleary
May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·R BaffaC M Croce

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