DNA repair by photolyases

Advances in Protein Chemistry and Structural Biology
Ibrahim Halil KavakliŞeref Gül

Abstract

Photolyases belong to the cryptochrome/photolyase protein family (CPF) which perform different functions such as DNA repair, circadian photoreceptor, and transcriptional regulation. Photolyase is a flavoprotein that repairs UV-induced DNA damages of cyclobutane pyrimidine dimer (CPD) and pyrimidine-pyrimidone (6-4) photoproducts using blue-light as an energy source. This enzyme has two chromophores: flavin adenine dinucleotide (FAD) as a cofactor and a photoantenna such as methenyltetrahydrofolate (MTHF). The FAD is essential for catalysis of the DNA repair. The second chromophore absorbs photons from the blue light spectrum and transfers energy to FAD to increase the repair efficiency of the enzyme. Phylogenetic analysis in which amino acid sequences of several hundreds of CPF members are used suggests that they form more classes than we have considered so far. In this chapter, we discussed structure-functions and reaction mechanisms of different classes of photolyases.

Citations

Sep 23, 2020·Extremophiles : Life Under Extreme Conditions·Juan José MarizcurrenaSusana Castro-Sowinski
Sep 17, 2020·International Journal of Molecular Sciences·Philippe Johann To Berens, Jean Molinier
Feb 23, 2020·Biochemistry. Biokhimii︠a︡·Yu L VechtomovaM S Kritsky
Oct 9, 2020·The Journal of Biological Chemistry·Seref GulIbrahim Halil Kavakli
Jan 1, 2021·Journal of Photochemistry and Photobiology. B, Biology·Nicolás RamírezCarminna Ottone
Jan 18, 2021·The Journal of Biological Chemistry·Seref GulIbrahim Halil Kavakli
Mar 1, 2021·Journal of the American Academy of Dermatology·Amaris N GeislerHenry W Lim
Oct 4, 2019·Biochemistry·Ugur Meric DikbasIbrahim Halil Kavakli

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