PMID: 420857Jan 26, 1979

DNA repair in a Fanconi's anemia fibroblast cell strain

Biochimica Et Biophysica Acta
A J FornaceR R Weichselbaum

Abstract

DNA repair and colony survival were measured in fibroblasts from a patient with Fanconi's anemia, HG 261, and from normal human donors after exposure of these cells to the cross-linking agent mitomycin C, X-rays or ultraviolet light. Survival was similar in HG 261 and normal cells after X-ray or ultraviolet radiation, but was reduced in the Fanconi's anemia cells after treatment with mitomycin C. The level of DNA cross-linking, as measured by the method of alkaline elution, was the same in both cell strains after exposure to various doses of mitomycin C. With incubation after drug treatment, a gradual decrease in the amount of cross-linking was observed; the rate of this apparent repair of cross-link damage was the same in both normal and HG 261 cells. The rejoining of DNA single strand breaks after X-irradiation and the production of excision breaks after ultraviolet radiation were also normal in HG 261 cells as determined by alkaline elution.

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Related Concepts

Hypoplastic Anemia
Cell Survival
DNA, Double-Stranded
Base Excision Repair
Fanconi Anemia
Mitomycins
Black Light, Ultraviolet
Roentgen Rays

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