DNA repair in Syrian hamster embryo cells treated with 7,12-dimethylbenz[a]anthracene and its weakly carcinogenic 5-fluoro analog

Cancer Letters
S M D'AmbrosioD T Witiak

Abstract

The postreplication repair capacity of Syrian hamster embryo cells in culture was determined after treatment with the potent carcinogen 7,12-dimethylbenz[a]anthracene (DMBA) and its weakly carcinogenic analog 5-F-DMBA. The size and amount of daughter DNA sedimenting as high-molecular-weight DNA were found to be less in the DMBA treated cells than in the 5-F-DMBA-treated cells. This difference probably depends upon the types of adducts entering DNA replication.

References

Aug 1, 1978·Photochemistry and Photobiology·R W HartF B Daniel
Aug 1, 1979·Cancer Letters·D S LongneckerW Noll
Jan 1, 1976·Annual Review of Biochemistry·J W Drake, R H Baltz
Jan 10, 1977·Biochemical and Biophysical Research Communications·D E Amacher, M W Lieberman
Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·S M D'Ambrosio, R B Setlow
Jan 1, 1975·Biochemical Society Transactions·P N MageeP F Swann
Mar 15, 1974·International Journal of Cancer. Journal International Du Cancer·E Huberman, L Sachs
Nov 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·R B SetlowW L Carrier

Citations

Feb 1, 1982·Photochemistry and Photobiology·R E Gibson, S M D'Ambrosio

Related Concepts

Metazoa
Benz(a)Anthracenes
DNA, Double-Stranded
Base Excision Repair
DNA Replication
Embryonic Structures, Mammalian
Cricetus
Mesocricetus
Structure-Activity Relationship
9,10-Dimethyl-1,2-benzanthracene

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