DNA repair in Syrian hamster embryo cells treated with 7,12-dimethylbenz[a]anthracene and its weakly carcinogenic 5-fluoro analog

Cancer Letters
S M D'AmbrosioD T Witiak


The postreplication repair capacity of Syrian hamster embryo cells in culture was determined after treatment with the potent carcinogen 7,12-dimethylbenz[a]anthracene (DMBA) and its weakly carcinogenic analog 5-F-DMBA. The size and amount of daughter DNA sedimenting as high-molecular-weight DNA were found to be less in the DMBA treated cells than in the 5-F-DMBA-treated cells. This difference probably depends upon the types of adducts entering DNA replication.


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Related Concepts

DNA, Double-Stranded
Base Excision Repair
DNA Replication
Embryonic Structures, Mammalian
Structure-Activity Relationship

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