DNA Repair Is Associated with Information Content in Bacteria, Archaea, and DNA Viruses

The Journal of Heredity
Sharlene AcostaSteven E Massey

Abstract

The concept of a "proteomic constraint" proposes that DNA repair capacity is positively correlated with the information content of a genome, which can be approximated to the size of the proteome (P). This in turn implies that DNA repair genes are more likely to be present in genomes with larger values of P. This stands in contrast to the common assumption that informational genes have a core function and so are evenly distributed across organisms. We examined the presence/absence of 18 DNA repair genes in bacterial genomes. A positive relationship between gene presence and P was observed for 17 genes in the total dataset, and 16 genes when only nonintracellular bacteria were examined. A marked reduction of DNA repair genes was observed in intracellular bacteria, consistent with their reduced value of P. We also examined archaeal and DNA virus genomes, and show that the presence of DNA repair genes is likewise related to a larger value of P. In addition, the products of the bacterial genes mutY, vsr, and ndk, involved in the correction of GC/AT mutations, are strongly associated with reduced genome GC content. We therefore propose that a reduction in information content leads to a loss of DNA repair genes and indirectly to a red...Continue Reading

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Citations

Nov 10, 2020·Microbial Genomics·Dimple DavrayRam Kulkarni
Dec 10, 2020·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·D DerilusS E Massey
Aug 9, 2020·Current Biology : CB·Thomas BourguignonNathan Lo
Oct 7, 2020·Current Biology : CB·Gabriel A B MaraisVincent Daubin

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