PMID: 7539281Apr 1, 1995Paper

DNA-repeat instability is associated with colorectal cancers presenting minimal chromosome rearrangements

Genes, Chromosomes & Cancer
Y RemvikosB Dutrillaux

Abstract

The DNA-repeat [(CA)n] instability of colorectal cancer cells was studied relative to our previously defined classification based on chromosome alterations. Of the 23 tumors analyzed, 13 belonged to the "monosomic" type (MT) characterized by simultaneous loss of chromosome 18 and chromosome arm 17p, and many structural rearrangements, 7 to the "trisomic" type (TT) with many chromosome gains but few rearrangements, and 3 had a normal karyotype (NT). (CA)n repeat sequences were examined on chromosomes 2, 5, 11, 13, 18, and 20. We found sequence alterations in 12 tumors at 1 or several loci, 9 of which (1/13 MT, 5/7 TT, and 3/3 NT) exhibited a typical shift in allele size defined as microsatellite instability. Furthermore, a single alteration was observed for the MT tumor, whereas one NT tumor displayed instability on two and all the other tumors on three or more loci. These results suggest an inverse relationship between the occurrence of chromosome structural rearrangements and microsatellite instability, providing another argument for the subdivision of colorectal cancers into groups of distinct oncogenic pathways.

References

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Citations

Aug 29, 2012·Pathology Oncology Research : POR·Joško BezićSnježana Tomić
Sep 28, 1998·Mutation Research·B LambertA Wennborg
Jan 1, 1997·Cancer Genetics and Cytogenetics·Y RemvikosB Dutrillaux
Oct 20, 1999·Cancer Genetics and Cytogenetics·L ChauveincB Dutrillaux
Aug 17, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B T HillA Kruczynski
Feb 1, 1997·Molecular Medicine Today·R A Lothe
Aug 12, 1999·BJU International·M C CrundwellS M Phillips
Oct 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·S OlschwangG Thomas
Mar 28, 2002·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·F PiardL Martin
May 13, 2008·Gastroenterology·Liudmila L KodachJames C H Hardwick
Jun 23, 2004·Oncogene·Romain MolistMartine Muleris
Aug 19, 2003·Nature Genetics·Donna G AlbertsonJoe W Gray
Jul 11, 2003·Oncogene·Antoine M SnijdersDonna G Albertson

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